Carbohydrate ligands

As an alternative to chemical S5uithesis, complex glycoproteins can be prepared by molecular biology techuiques [30,31]. Typically, the recombinant protein is expressed in mam- 

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L. L. Kiessling, J. K. Pontrello, and M. C. Schuster, Synthetic multivalent carbohydrate ligands as effectors or inhibitors of biological processes, in C.-H. Wong, (Ed.), Carbohydrate-Based Drug Discovery, Wiley-VCH Weinheim, Germany, 2003, pp. 575-608. 

P. I. Kitov, J. M. Sadowska, G. Mulvey, G. D. Armstrong, H. Ling, N. Pannu, R. J. Read, and D. R. Bundle, Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands, Nature, 403 (2000) 669-672. 

N. V. Bovin and H.-J. Gabius, Polymer immobilized carbohydrate ligands versatile chemical tools for biochemistry and medical science, Chem. Soc. Rev., 24 (1995) 413—421. 

A. Dondoni, M. Kleban, X. Hu, A. Marra, and H. D. Banks, Glycoside-clustering round calixarenes toward the development of multivalent carbohydrate ligands. Synthesis and conformational analysis of calix[4]arene O- and C-glycoconjugates, J. Org. Chem., 67 (2002) 4722 -733. 

G. D. Armstrong, Assessment in mice of the therapeutic potential of tailored, multivalent Shiga Toxin carbohydrate ligands, J. Infect. Dis., 187 (2003) 640-649. 

S. Sakai, Y. Shigemasa, and T. Sasaki, A self-adjusting carbohydrate ligand for GalNac specific lectins, Tetrahedron Lett., 38 (1997) 8145-8148. 

Table 15.1 Glycodendrimers showing the carbohydrate ligands and their applications...

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