The Carbohydrate Ligands

Gal/GalNAc or Man/GlcNAc, there are also receptors (e.g., the macrophage sialic acid receptor) for the recognition of sialylated complex glycans.10 

The tetra-antennary oligosaccharide has been shown to present an umbrella-like structure as one of the major conformational populations [15,16]. The distance between terminal sugar residues interacting with receptors may vary from 8 to 30 A. In the case of the phosphorylated high-mannose ligands for the MPR the distance is -15 A [17]. In biolog- 

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Table 15.1 Glycodendrimers showing the carbohydrate ligands and their applications...

From the protein perspective, there are also cases in which the protein skeleton is perfectly preorganized to accommodate the carbohydrate ligand, as reported for the hevein family.288 289 However, cases in which a major... 

The carbohydrate ligand for E-selectin on leukocytes contains the sLe" epitope (74). Because the C-type lectin domains of E- and P-selectins are highly homologous, it was no surprise that sLe" serves as a ligand also for P-selectin (75). 

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