Methotrexate Carbenicillin

Bleomycin Bleomycin is incompatible and loses its potency if it is administered with solutions of benzylpenicillin sodium, carbenicillin, cephazolin or cephalothin sodium, hydrocortisone sodium succinate, mitomycin, methotrexate, nafcillin sodium, aminophylline, ascorbic acid, terbutaline, divalent and trivalent cations (especially copper), compounds containing sulfhydryl groups, and precipitation by hydrophobic anions, essential amino acids, riboflavine, dexamethasone, and frusemide. 

Clinically important, potentially hazardous interactions with amoxicillin, ampicillin, antacids, bacampicillin, calcium carbonate, carbenicillin, cloxacillin, digoxin, methotrexate, methoxyflurane, mezlocillin, nafcillin, oxacillin, penicillins, piperacillin, ticarcillin, zinc... 

Clinically important, potentially hazardous interactions with acitretin, aluminum hydroxide, amoxicillin, ampicillin, antacids, bacampicillin, betamethasone, bismuth, bromelain, calcium, carbenicillin, cholestyramine, doxacillin, corticosteroids, dairy products, dicloxacillin, didanosine, digoxin, food, glidazide, iron, isotretinoin, methicillin, methotrexate, methoxyflurane, mezlocillin, nafcillin, oxacillin, penicillins, piperacillin, retinoids, rocuronium, strontium ranelate, sucralfate, ticarcillin, vitamin A, zinc... 

Reduced clearance and acute methotrexate toxicity has been attributed to the concurrent use of various penicillins (amoxicillin, benzylpenicillin, carbenicillin, dicloxacillin, flucloxacillin, mezlocillin, oxacillin, penicillin, phenoxymethylpenicillin, piperacillin, ticarcillin) in a small number of case reports. 

Intravenous infusion 6 g/m (10.8 g) over one hour, then 1.2 gfm per hour for 23 hours Carbenicillin (30 g daily) Acute lymphoblastic leuloiemia (1) Elevated plasma methotrexate levels and decreased methotrexate clearance 2... 

Gibson DL, Bleyer AW, Savitch JL. Carbenicillin potentiation of methotrexate plasma concentration during high dose methotrexate therapy. American Society of Hospital Pharmacists. Mid year clinical meeting abstracts. New Orleans, Dec 1981. p. 111. 

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