E-Amino caproic acid

Calcium carbide, 32, 70 Calcium carbonate, 32, 81 Calcium formate, 31,102 CAPROIC ACID, e-AMINO, 32, 13 e-Caprolactam, 31, 72 32, 15 e-CAPROLACTIM, O-METHYL-, 31, 72 CAPRONITRILE, a-ETHYL, 32, 6S Caproyl chloride, 31, 71 CARBANILINONITRILE, O-CHLORO, 31, 19... 

Johansson SA. Acute right heart failure during treatment with epsilon amino caproic acid (E-ACA). Acta Med Scand 1967 182(3) 331. ... 

Various other compounds are used clinically as antifibrinolytics. As mentioned above, aprotinin, a small polypeptide that inhibits plasmin, trypsin and kallikrein, is often used in coagulation tlierapy and in fibrin sealant formulations (Trautschold et al, 1967). In the latter applications, the aprotinin serves to delay the fibrinolytic action of plasmin until the fibrin has fiilfilled its function. A monoamino carboxylic acid, e-amino caproic acid, is similar in structure to lysine and interacts with the active kringles or lysine-binding sites of plasminogen and plasminogen activators to inhibit their binding to fibrin and thus their fibrinolytic actions (Thorsen, 1992). This compound is also used in some clinical applications. 

Metabolism of NHEX- C in the rat results in dose dependent formation of C02> with 45% exhaled after a dose of 8 mg/kg NHEX but only 4% after 576 mg/kg (17). Similar results were obtained for NPYR and nitrosoheptamethyleneimine. At doses of 8-12 mg/kg NHEX, 33-37% of the radioactivity was excreted in the urine (17, 52). Urinary metabolites of NHEX were e-caprolactam, e-amino-caproic acid, and 6-aminocaprohydroxamic acid (52). The formation of 6-caprolactam is analogous to results with NPYR and NNN, in which 2-pyrrolidinone and norcotinine were observed as urinary metabolites. Caprolactam did not originate from hexamethylene-imine, a product of denitrosation. 

Hydrolytic polymerization of e-caprolactam to form nylon 6 (Sec. 2-8f) is carried out commercially in both batch and continuous processes by heating the monomer in the presence of 5-10% water to temperatures of 250-270°C for periods of 12 h to more than 24 h [Anton and Baird, 2002 Zimmerman, 1988]. Several equilibria are involved in the polymerization [Bertalan et al., 1984 Sekiguchi, 1984]. These are hydrolysis of the lactam to e-amino-caproic acid (Eq. 7-56), step polymerization of the amino acid with itself (Eq. 7-57), and initiation of ring-opening polymerization of lactam by the amino acid. The amino acid is... 

Condensation polymerisation occurs when multifunctional monomers, which possess more than one chemically reactive group per molecule, react together with the elimination of small molecules, typically either water or HC1. With a bifunctional monomer the product is a linear polymer, e.g. the polyamide Nylon-6 is derived from e-amino caproic acid as follows ... 

Jordan D, Delphin E, Rose E. Prophylactic epsilon-amino-caproic acid (EACA) administration minimizes blood replacement therapy during cardiac surgery. Anesth Analg 1995 80(4) 827-9. 

The interaction of a non-enzymatic degradation product, D-benzylpenicillenic acid (formed by cleavage of the thiazolidine ring of benzylpenicillin in solution see Fig. 10.3B), with sulphydryl or amino groups in tissue proteins, to form hapten-protein conjugates, is also of importance. In particular, the reaction between D-benzylpenicillenic acid and the e-amino group of lysine (a,e-diamino- -caproic acid, NH2(CH2)4.CH(NH2).COOH) residues... 

Other, nontested, proposed regimens of dubious value include prostaglandin Ej, surfactant, antihistamines, asparaginase, calcium, atropine, anticoagulants, e-amino caproic acid, urease, hypothermia, and extra-corporeal oxygenation (34). 

Amino acids from their hydrochlorides. jS-Alanine can be isolated from an aqueous solution of the crude hydrochloride by stirring with moist, precipitated silver oxide, filtering, and treating the filtrate with hydrogen sulfide. For recovery of e-amino-caproic acid from the hydrochloride, Eck used two portions of powdered litharge and 1 portion each of precipitated lead hydroxide and silver oxide, followed by treatment with hydrogen snlfide. 

Although water induces the polymerization, the true initiating species is the amino-caproic acid formed by hydrolysis. This acid is usually added to accelerate the polymerization. The preliminary formation of aminocaproic acid by hydrolysis of eCLM explains the increase in polymerization rate with increaseing [H20]. Some other carboxylic acid derivatives are also used in practice e.g. the hexamethylene diamine salt of the adipic acid (so called 6,6 salt). 

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