Cancer optical sensor

Taking a product from development to successful PMA usually requires at least seven years. The average time to FDA approval once all required testing is completed and submitted for review is 2-5 years [2. Lewin, N. Faster approvals seen for drug and device combination products. BBI Newsletter 2003 26(9).] Given the time and expense involved, a company must try to predict whether their product, nearly a decade in the future, will fill a significant market need and be profitable. Examples of PMA devices approved in the past include an artificial urinary sphincter a penile infiatable implant and electro-optical sensors for in vivo detection of cervical cancer. [3. http //www.fda.gov/cdrh/devadvice/pma/ (accessed October 2005).]... 

Bisphenol A (BPA) is a common compound used in the synthesis of many plastics and epoxy resins. However, recent studies have determined BP A is an emerging contaminant, which can disrupt the endocrine system and potentially cause cancer [115]. By molecular imprinting, Gao s group created numerous nanocavities in polymethyl methacrylate (PMMA) spheres, which can specifically target BPA (Fig. 37). The monodisperse PMMA spheres can be made into a CCA-based optical sensor. When the sensor is exposed to BPA solution, binding... 

The novel water-soluble dye 64 shows sufficient stability for potential application in molecular-based beacons for cancer detection using optical imaging <2005BCC735>. An optochemical ozone sensor with a quantitation limit of 0.03 ppm and accuracy exceeding 8% has been obtained by immobilization of the novel soluble indigo derivative 65 in permeable transparent polymeric films of polydimethylsiloxane-polycarbonate <2005MI1628>. 

Phthalocyanines have been targeted for a wide variety of applications including colour dyes, electrochromics, detection of conductivity changes (sensors), non-hnear optics and photodynamic therapy for the destruction of cancer cells. 

Nanofibre nonwovens focused on defence and security include applications such as chemical and biological protection, and composite reinforcement and sensors (optical, chemical, gas). Soldiers can be exposed in the battlefield to harmful chemicals and biological agents from explosives. Chemical and biological warfare agents, such as mustard gas, covalently bond with DNA or forms disulphide bonds with thiol groups, which leads to cell death or eventually to cancer [42]. Nanofibre developments are... 

Finally, in optical-based sensors and assays, there is the development of label-free bioanalytic detection on prepared membrane surfaces, ultra sensitive detection of microbial agents, the development of fiber-optic based enzyme sensors, multi-analyte breast cancer immunoassays, and photodynamic therapy of osteosarcoma in veterinary patients. 

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