Cancer High malignancy

An, Z. L., Wang, X. E Kubota, T., Moossa, A. R. and Hoffman, R. M. (1996). A clinical nude mouse metastatic model for highly malignant human pancreatic cancer. Anticancer Res. 16, 627-631. 

Dennis, J. W., Donaghue, T. P. and Kerbel, R. S. (1981). Membrane-associated alterations detected in poorly tumorigenic lectin-resistant variant sublines of a highly malignant and metastatic murine tumor. J. Natl. Cancer Inst. 66, 129-137. 

Mendillo, M.L., Santagata, S., Koeva, M., Bell, G.W., Hu, R., Tamimi, R.M., Fraenkel, E., Ince, T.A., Whitesell, L., and Lindquist, S. 2012. HSFl drives a transcriptional program distinct from heat shock to support highly malignant human cancers. 150, 549-562. 

Matsuda Y, Yamakawa K, Saoo K, Hosokawa K, Yokohira M, Kuno T, Iwai J, Shirai T, Obika K, Kamataki T, Imaida K (2007) CYP2A6 overexpression in human lung cancers correlates with a high malignant status. Oncol Rep 18 53-57... 

Adrenal cortical carcinomas are rare, highly malignant tumors which account for only 0.2% of deaths due to cancer in the United States. Their incidence has been estimated a two per milhon per year. About half of these tumors produce hormonal and metabolic syndromes that lead to their discovery. The other half are silent and are defined with the appearance of metastasis or when the primary tumor becomes large enough to produce abdominal symptoms. While adrenal cancer can occur at any age, most cases are discovered between the ages of 30-50 years (Brennan 1987 Schteingart 2000). 

Subglottic carcinoma is a very rare entity with an incidence of about 1.5% (ZiNREicH 2002). Nevertheless, this subtype of laryngeal cancer has the worst prognosis and is highly malignant. The carcinoma of the subglottic region tends to spread to the trachea or invade the... 

A principal appHcation for photomedicine is the photodynamic treatment of cancer. Photochemical and clinical aspects of this topic have been reviewed (10,11). Direct irradiation of tumors coupled with adininistration of a sensitizer is used to effect necrosis of the malignancy. In this process, an excited state sensitizer interacts with dissolved in vivo to effect conversion of the oxygen from its triplet ground state to an excited singlet state, which is highly cytotoxic. In principle, excited sensitizers in either the singlet or the triplet state can effect this conversion of molecular oxygen (8). In... 

Several kinds of cancer therapy use radiation to destroy malignant cells. Boron neutron capture therapy is unusual in that boron-10, the isotope injected, is not radioactive. However, when boron-10 is bombarded with neutrons, it gives off highly destructive a particles. In boron neutron capture therapy, the boron-10 is incorporated into a compound that is preferentially absorbed by tumors. The patient is then exposed to brief periods of neutron bombardment. As soon as the bombardment ceases, the boron-10 stops generating a particles. 

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