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Cancer Cells Calcium

Gray, L. S. and Macdonald, T. L., 2006, The pharmacology and regulation of T type calcium channels new opportunities for unique therapeutics for cancer. Cell Calcium 40, 115-20. [Pg.422]

Rodland, K. D., 2004, The role of the calcium-sensing receptor in cancer. Cell Calcium 35, 291-5. [Pg.425]

The CaR regulates numerous biological processes, including the expression of various genes (e.g., PTH) the secretion of hormones (PTH and calcitonin), cytokines (MCP-1), and calcium (e.g., into breast milk) the activities of channels (potassium channels) and transporters (aquaporin-2) cellular shape, motility (of macrophages), and migration cellular adhesion (of hematopoietic stem cells) and cellular proliferation (of colonocytes), differentiation (of keratinocytes), and apoptosis (of H-500 ley dig cancer cells) [3]. [Pg.303]

Verapamil has been shown to block the P-glycoprotein responsible for the transport of many foreign drugs out of cancer (and other) cells (see Chapter 1) other calcium channel blockers appear to have a similar effect. This action is not stereospecific. Verapamil has been shown to partially reverse the resistance of cancer cells to many chemotherapeutic drugs in vitro. Some clinical results suggest similar effects in patients (see Chapter 54). Animal research suggests possible future roles of calcium blockers in the treatment of osteoporosis, fertility disorders and male contraception, immune modulation, and even schistosomiasis. [Pg.262]

Wield R, Franz C, Scholl FA, Heizmann CW, Schafer BW. 1997. Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site-specific hypermethylation. Cell Calcium 22(4) 243-254. [Pg.136]

Rodriguez-Mora, O. G., LaHair, M. M., McCubrey, J. A. and Franklin, R. A., 2005, Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells, Cancer Res, 65, pp 5408-16. [Pg.211]

Lee, W.J., Roberts-Thomson, S.J., Monteith, G.R., 2005a, Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines. Biochem Biophys Res Commun 337, 779-783. [Pg.380]

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