Campylobacter fetus

Studies on S-layers present on the cell envelopes of a great variety of pathogenic organisms [100] revealed that these crystalhne arrays can represent important virulence factors. Most detailed studies have been performed on the fish pathogenic bacteria Aeromonas salmonicida and Aeromonas hydrophila [102] and the human pathogen Campylobacter fetus uh p. fetus [103] and Bacillus anthracis [104]. For example, whole-cell preparations or partially purified cell products are currently used as attenuated vaccines against various fish pathogens [102,105]. 

Enteric disease Salmonella spp. Shigella spp, Campylobacter fetus... 

Miscellaneous infections caused by susceptible strains of bacteria causing psittacosis, cholera, melioidosis, leptospirosis, brucellosis, bartonellosis, plague, tularemia, Campylobacter fetus infection, rickettsial infections including typhus and Q fever, relapsing fever due to Borrelia recurrentis and actinomycosis in penicillin allergic patients. 

Microorganisms sometimes control the synthesis of surface proteins using segments of invertible DNA. The pathogenic bacterium Campylobacter fetus utilizes DNA rearrangements to allow one of a large family of surface layer (S-layer) proteins to be formed.597 The yeast FLP recombinase, mentioned in the preceding section, also inverts the sequence flanked by the 599-bp repeats.589... 

Perez, G.I., Hopkins, J.A., Blaser, M.J. Antigenic heterogeneity of lipopolysaccharides from Campylobacter jejuni and Campylobacter fetus. Infect Immun 48 (1985) 528-533. 

Antihelmintic [305], antibacterial [306], aerobic, microaerobic, anaerobic activity [307, 308], against Salmonella typimurium, Campylobacter spp. Bacteroides spp. [192], T. vaginalis [309, 310], Schistosoma haematobium, Schistosoma mansoni, [310, 311], Salmonella [312], Campylobacter fetus subsp. jejuni [313], toxicity in hypoxic cells, structure-activity [127] Aerobic, vicroaerobic, anaerobic activity [307]... 

S. N. Senchenkova, A. S. Shashkov, Y. A. Knirel, J. J. McGovern, and A. P. Moran, The O-specific polysaccharide chain of Campylobacter fetus serotype E lipopolysaccharide is a D-rhamnan terminated with 3-O-methyl-D-rhamnose (D-acofriose), Eur. J. Biochem., 239 (1996) 434-438. 

A similar surface protein layer has been found to play a role in virulence in the animal and human pathogen Campylobacter fetus subsp. intestinalis. This is also a hydrophobic protein, but unlike the A protein of Aeromonas... 

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