Caloric restriction life span effects

McShane TM, Wise PM (1996) Life-long moderate caloric restriction prolongs reproductive life span in rats without interrupting estrous cyclicity effects on the gonadotropinreleasing hormone luteinizing hormone axis. Biol Reprod 54 70-75... 

In humans the possibility of mimicking caloric restriction by addition of supplements, fiber, micronutrients, and others that form the group of geronto-ceuticals (i.e., potential antiaging cocktails that may mimic the metabolic or physiological effects of CR) bodes well for the possibility that the extended life and health spans associated with lower body temperature and insulin levels may ultimately be attainable without reduced food consumption or appetite.10... 

TAC of blood plasma in rats fed an ethanol-supplemented diet increases, although ethanol is known to induce oxidative stress. The effect is due to ethanol-induced purine degradation and increase in the level of uric acid (G2). TAC of blood plasma in critically ill patients with renal dysfunction is augmented, again due to increase in uric acid level (Ml). Caloric restriction, a procedure known to improve the redox status and prolong the life span of mammals, decreases TAC of rat serum (C12). 

It has been repeatedly demonstrated that caloric restriction in laboratory animals results in increased longevity. Thus, McCay and co-workers (Mil) first demonstrated that by restricting food intake of young rats, their longevity could be significantly increased. Subsequent studies showed that food restriction in adult rats is also effective in increasing their life span (Y7). In fact, the life span of various... 

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