Cadmium carcinogenesis

Waalkes, M.P., S. Rehm, C.W. Riggs, R.M. Bare, D.E. Devor, L.A. Poirier, M.L. Wenk, and J.R. Henneman. 1989. Cadmium carcinogenesis in male Wistar [Crl (Wl)BR] rats dose-response analysis of effects of zinc on tumor induction in the prostate, in the testes, and at the injection site. Cancer Res. 42 4282-4288. 

Waalkes MP (2000) Cadmium carcinogenesis in review. J Inorg Biochem 79 241-244. 

Zinc acetate reduced or prevented cadmium carcinogenesis in the prostate, in the testes, or at the injection site in rats (Gunn et al. 1963a, 1964 Waalkes et al. 1989). The effect of zinc on the cadmium-induced carcinogenesis appeared to be dependent on dose, route, and target site. Sustained levels of zinc inhibited cadmium-induced injection sarcomas but had no effect on the incidence of testicular Leydig cell tumors (Waalkes et al. 1989). 

Waalkes et al. 1991a), indicating a genetic basis of susceptibility. It has been concluded from other mechanistic studies that the susceptibility of some tissues, e.g., testes and prostate, to cadmium carcinogenesis may be related to the relative lack of metallothionein in these tissues (Waalkes et al. 1989, 1992a, 1993a), which would reduce the capacity of these tissues to detoxify cadmium. 

Waalkes MP, Oberdorster G (1990) Cadmium carcinogenesis. In Foulkes EC (ed) Biological effects of heavy metals, vol II metal carcinogenesis. CRC Press, Boca Raton, FL, pp 129-158... 

Waalkes MP, Rehm S, Riggs CW, Bare RM, Devor DE, Poirier LA, Wenk ML, Henneman JR, Balaschak MS (1988a) Cadmium carcinogenesis in the male... 

Waalkes MP, Perantoni A, Rehm S (1989) Tissue susceptibility factors in cadmium carcinogenesis. Correlation between cadmium-induction of prostatic tumors in rats and an apparent deficiency of metallthionein. Biol Trace Elem Res 21 483-490... 

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