C-Abl tyrosine kinase

Wen, S.-T, Van Etten, R. A. (1997). The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity. Genes Dev. 11, 2456-2467. 

Kharbanda S, Kumar V, Dhar S, Pandey P, Chen C, et al. 2000. Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase. Curr. Biol. 10 568-75... 

The c-Abl tyrosine kinase participates in a variety of cellular functions, including regulation of the actin cytoskeleton, regulation of the cell cycle, and the apoptotic/cell cycle arrest response to stress the Abl family of kinases also play a crucial role in development of the CNS. c-Abl activation has been reported in AD and... 

The prototype molecularly targeted therapeutic agent is imatinib, an inhibitor of the Bcr-Abl tyrosine kinase. This oncogenic kinase is produced by translocation of the Bcr locus on chromosome 9 to the c-Abl tyrosine kinase on chromosome 11, termed the Philadelphia chromosome because of its discovery in 1960 at the University of Pennsylvania School of Medicine by Peter Nowell and David Hungerford from the Institute for Cancer Research [9]. It was later demonstrated in 1973 by Janet Rowley that the Philadelphia translocation was responsible for a specific form of leukemia, chronic myelogenous leukemia (CML) [10], In 2001, imatinib was approved for treatment of CML patients, and produced remarkable results with more than 92% patients achieving 14-month progression-free survival on imatinib as a monotherapy. 

Glover, R. T, Angiolieri, M., Kelly, S., Monaghan, D. T, Wang, J. Y, Smithgall, T. E., and Buller, A. L. (2000). Interaction of the A-methyl-D-aspartic acid receptor NR2D suhunit with the c-Abl tyrosine kinase./. Biol. Chem. 275, 12725-12729. 

Lewis JM et al (1996) Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport. Proc Natl Acad Sci USA 93 15174-15179... 

Perkinton MS et al (2004) The c-Abl tyrosine kinase phos-phorylates the Fe65 adaptor protein to stimulate Fe65/ amyloid precursor protein nuclear signaling. J Biol Chem 279 22084-22091... 

Pugazhenthi S et al (2000) Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem 275 10761-10766 Raina D et al (2005) c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J Biol Chem 280 11147-11151... 

Yoshida K et al (2002) c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. Mol Cell Biol 22 3292-3300 You H et al (2006) FOX03a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Medicine 203 1657-1663... 

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