2, 3-butanedione monoxime

Another irreversible approach was performed by using bis(2,3-butanedione monoxime) alkanedioates as diester substrate [45]. Lipase MM efficiently produced the polymer with Mn up to 7.0 x 103. 

Reactive oximes and their salts, such as potassium 2,3-butanedione monoximate found in commercially available RSDL, are extremely effective at rapidly detoxifying nerve agents. Some chloroisocyanurates, similar to those found in the CASCAD, are effective at detoxifying V-series agents and so is oxone, a peroxymonosulfate triple salt. 

Butane-2,3-dione dioxime, 1590 2,3-Butanedione monoxime, 1565 t 2-Butanethiol, 1707 t Butanethiol, 1706... 

When an isonitrosoketone reacts with an aldoxime, the product is an imidazole W-oxide.122 In a similar reaction Allan and Allan123 prepared 1-hydroxyimidazoles by the reaction of 2,3-butanedione-monoxime with aldehydes in aqueous ammonia. The overall reaction is undoubtedly the reaction of the isonitrosoketone with an aldimine by a mechanism similar to the following ... 

In the open literature little is known about these agents developed in the Soviet Union. They are assessed to be five to ten times more toxic than VX (Ellison, 2008 Smithson et al, 1995). The toxicity of these binary agents does not rely primarily on the inhibition of AChE, but it is thought that it causes permanent neuropathy. Consequently, conventional nerve agent antidotes may not work. Reactive oximes such as potassium 2,3-butanedione monoximate may be use fid in detoxification. No pubhshed information is available on cardiac pathologies caused by Novichok agents. 

Reactive Skin Decontamination Lotion (RSDL) has recently been approved for procurement by the U.S. military (F-Z-EM 2007). RSDL is currently marketed by E-Z-EM, Inc. and is a patented, broad spectrum, skin decontamination lotion that is used to remove or neutralize chemical threat agents and biological warfare agents such as trichothecene mycotoxin (T2 toxin), which can cause severe skin and eye irritation. RSDL was originally developed by the Canadian Defense Research Establishment and consists of 1.25 molar potassium 2,3-butanedione monoximate in poly-etheylene glycol monoethyl ethers with 10% w/v water (Sabourin et al. 2001 Lukey et al. 2004). 

RSDL. In 1995, the Canadian Defense Research Establishment at Ottawa and Suffield developed and patented a liquid skin decontaminant for CWA exposure named RSDL. RSDL is a formulation of potassium 2,3-butanedione monoxime (as free oxime and potassium salt) in a solvent of polyethylene glycol monomethylether (MPEG) of 550 nominal molecular weight with 10% w/w water (pH 10.6) (Sabourin et al., 2001 Bide et al., 2005 Material Data Safety Sheet, 2006). 

Despite reports to the contrary <84CHEC-I(3)1039>, it is now known that 1,2,5-oxadiazines are not extremely common systems. Reports on their synthesis by self-condensation of ketoaldehyde monoximes in concentrated mineral acid <1897CB1292. 07CB4052>, and by the condensation of 2,3-butanedione monoxime with aldoximes <05CB3357>, have been shown to be incorrect (see Section... 

As noted previously, myosin is located both in the lamellipodium and uropod of polarized cells [91, 401]. Whereas the myosin inhibitor, 2,3-butanedione monoxime, inhibits lamellapodial extension at high concentrations, at intermediate concentrations cell polarization and lamellipodium extension occur, but uropod retraction is inhibited, clearly indicating a role for myosin-mediated contractile forces in uropod retraction [91, 398]. The inhibitor, 2,3-butanedione monoxime, inhibits multiple forms of myosin [72], thus lamellapodial extension and uropod retraction may be mediated by different forms of myosin. 

Urwyler, N., Eggli. P. and KeUer, H.U. (2000). Effects of the myosin inhibitor 2,3-butanedione monoxime (BDM) on ceU shape, locomotion and fluid pinocytosis in human polymorphonuclear leukocytes. Cell Biol. Inti. 24, 863-870. 

Bis(2,3-butanedione monoxime) alkanedioates were employed as monomers for polyester production [70]. Lipase MM-catalyzed polymerization of a glutarate derivative with 1,6-hexanediol in diisopropyl ether produced a polymer with a molecular weight of 7.0 x 10 in 80% yield. 

Kiriazis H and Gibbs CL (1995) Papillary muscles split in the presence of 2,3-butanedione monoxime have a normal energetic and mechanical properties. Am J Physiol 269 H1685-H1694. 

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