1.4- Butanediol vinyl ether

As Figure 14 also shows, the only acetylene derivatives to sustain growth during this period were the so-called acetylenic chemicals. These include 1,4-butanediol, vinyl ethers, A/-vinyl-2-pyrroHdinone, and butanediol. Of these, 1,4-butanediol, a principal feed for tetrahydrofuran, accounts for over 90% of the acetylenic chemicals demand (38). 

Vinyloxy)butyl-9-acridinecarboxylate, cf.. Figure 3.27, is synthesized from 9-acridine carboxylic acid hydrate and 1,4-butanediol vinyl ether. 

The principal commercial vinyl ethers are methyl vinyl ether (methoxyethene, boiling point 5.5°C, density 0.7311, flash point -56°C) ethyl vinyl ether (ethoxyethene, boiling point 35.7°C, density 0.7541, flash point -18°C) and butyl vinyl ether (1-ethenyloxybutane, boiling point 93.5°C, density 0.7792, flash point -1°C). Others such as the isopropyl, iso-butyl, hydroxybutyl, decyl, hexadecyl, and octadecyl ethers, as well as the divinyl ethers of butanediol vinyl ethers are miscible with nearly all organic solvents. 

Commercial EVAL hollow-fiber membranes prepared via the copolymerization of ethylene and vinyl alcohol have been recently explored for protein immobilization. L-Histidine has been coupled onto EVAL-fibers activated with epichlo-rohydrin or butanediol diglycidyl ether to prepare an affinity support for immunoglobulin G (IgG) purification [58]. Furthermore, histidine-immobilized hollow-fiber membranes have been employed for endotoxin removal from... 

Enzyme binder (carrier) Ethyl vinyl ether ENZYME CARRIER 1,4-Butanediol divinyl RESINS W. Germany 2,062,818 1972 Merck G.m.b.H. 

An optically pure chiral alkene-Fp complex is formed by reaction of the (Z)-2-butene-Fp complex with (/ ,R)-2,3-butanediol. Nucleophiles are added to this complex in a complete stereoselective way. Ring opening of the cyclic alkyl-Fp complexes with trimethylsilyl triflate leads to substituted vinyl ether-Fp complexes as pure enantiomers. The configurational stability of those complexes is limited, however, which requires immediate demetalation to the organic products (Scheme 4-75). ... 

A munber of other synthetic polymer networks have been developed and commercialised for liquid chromatography including polyvinylacetate cross-linked with butanediol divinyl ether, Merkogel GPC packings (Merck), polyvinylalcohol, Frac-togel and Toyopearl (Toyo Soda), a hydroxylated acrylic monomer cross-linked with a bifunctional agent, Trisacryl (Sepracor) and a hydrophilic vinyl polymer, TSKgel PW (Toyo Soda). 

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