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Butanamides, 3- -3-methyl

S. Wagner, H.J. Breyholz, M.P. Law, A. Faust, C. Holtke, S. Schroer, G. Haufe, B. Levkau, O. Schober, M. SchMers, K. Kopka, Novel fluorinated derivatives of the broad-spectrum MMP inhibitors A/-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](ben-zyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET, J. Med. Chem. 50 (2007) 5752-5764. [Pg.139]

The dark colored reaction mixture was transferred into 5.76 mol 2 N hydrochloric acid with rapid stirring for 1 hour. The aqueous phase was removed, and 0.8 L 15 weight % ammonium chloride in water was added to the organic phase. The resulting mixture was stirred at 35-40°C for 10 min, the aqueous phase then removed, and hexanes (2.4 L) added. The resulting suspension was cooled to -20°C and maintained at that temperature for a few minutes. The precipitate was filtered in a 300 mL sintered glass funnel and washed with hexanes (1 L). Drying of the solid under vacuum at 25-30°C yielded 4-chloro-N-methyl-N-phenyl-2-(2-pyrrolyl)butanamide (81% yield). [Pg.2002]

A solution of 4-chloro-N-methyl-N-phenyl-2-(2-pyrrolyl)butanamide in toluene was added dropwise at 85°C over 40 min to 1 hour to a stirred suspension of ALIQUAT 336 (phase transfer catalyst, 2 mol % with respect to pyrrolylbutanamide) and granular sodium hydroxide (3 equivalents) in toluene (50 mL). After the addition was complete, the suspension was stirred under a nitrogen atmosphere at a temperature of 85°C for 30 min, then cooled to 35°C. Cooled water (200 mL) was rapidly added to the mixture and stirred for 15 min at 25°C. The solution was rinsed with water and the layers were separated. The organic layer was washed with water, then distilled under atmospheric pressure to recover the toluene and water. The resultant solution was cooled to 50°C and allowed to crystallize after the addition of hexane and a seed crystal. The suspension was cooled to 5°C and stirred for 15 minutes. The resultant precipitate was filtered, washed with 100 mL of hexane, and dried under vacuum at 25°C to yield approximately 38 g (63%) N-methyl-N-phenyl-2,3-dihydro-lH-pyrrolizine-l-carboxamide. This solid was recrystallized from toluene to yield colorless crystals of N-methyl-N-phenyl-2,3-dihydro-lH-pyrrolizine-l-carboxamide, melting point 112-112.5°C. [Pg.2003]

Methyl-2R-[[[4-[(3-methylphenyl)thio]phenyl]-sulfonyl]-[2-(4-morpholinyl)-ethyl] amino]-N-[(tetrahydro-2H-pyran-2-yl)oxy]butanamide... [Pg.599]

Ans. Butanamide > butanoic acid > 1-pentanol = pentanal = methyl propanoate > hexane. The order is similar to the order of boiling points except that the alcohol, aldehyde, and ester have the same solubility. Although neither the aldehyde nor the ester can hydrogen-bond with itself, each can hydrogen-bond with water. [Pg.331]

Synonyms 2-Bromo-3,3-dimethyl-N-N-(a-a-dimethylbenzyl) butyramide 2-Bromo-3,3-dimethyl-N-(l-methyl-l-phenylethyl) butyramide Butanamide, 2-bromo-3,3-dimethyl-N-(l-methyl-l-phenylethyl)-Empirical Ci H22BrNO Properties M.w. 312.25... [Pg.561]

Butadiene/styrene polymer 1,3-Butadiene/styrene polymer Butadiene/styrene resin 1,3-Butadiene/styrene resin Butadiene/styrene rubber. See Styrene/butadiene polymer Butadiene. See Diacetyl Butal Butaldehyde Butalyde. Seen-Butyraldehyde Butamben. See Butyl PABA Butanal n-Butanal. See n-Butyraldehyde Butanal, 2-ethyl-. See 2-Ethylbutyraldehyde 1-Butanal, 3-methyl-. See Isovaleraldehyde Butanal, 2-methyl-. See 2-Methylbutyraldehyde Butanal, 3-(3-(1-methylethyl) phenyl)-. See Isopropylphenylbutanal Butanal oxime. See m-Butyraldehyde oxime Butanamide, 2-bromo-3,3-dimethyl-N-(1-methyl-1-phenylethyl)-. See Bromobutide Butanamide, 2-(4-chloro-2-nitrophenyl) azo)-N-(2,3-dihydro-2-oxo-1H-benzimidazo-5-yl)-3-oxo-. See Pigment orange 36 Butanamide, 2-((4-chloro-2-nitrophenyl) azo)-n-(2-methoxyphenyl)-3-oxo-. See Pigment yellow 73... [Pg.580]

Another example of DKR of amines was reported by Kanerva s group in 2004. In this case, the DKR of the methyl esters of proline and pipecolic acid was based on the acylation of the secondary amino group of the amino esters with vinyl butanoate by Candida antarctica lipase A. Acetaldehyde, used as a racemising agent, was released in situ from vinyl butanoate in the presence of TEA, allowing proline and pipecolic add methyl esters to be acylated in the forms of highly enantiopure butanamides (Scheme 3.51). [Pg.174]

O. Kirino, C. Takayama, and A. Mine, J. Pesticide Sd. Nippon Noyaku Gakkaishi), 11, 611 (1986). Herbicidal Activity of N-Benz butanamides. VIII. Quantitative Structure-Activity Relation of Herbicidal N-(l-Methyl-l-phenyleihyl)phenylacetamides. [Pg.370]

The suffix for amides is -amide. If there are substituents on the nitrogen atom (as opposed to those on the carbon chain where they are numbered in the usual way with the carbonyl carbon as C-1), then they are written as Af-ethyl or MiST-dimethyl. So 15.9 is butanamide and 15.10 is 3-ethyl-Af-methyl hexanamide. [Pg.668]

Heptafluoro-A -methyl-A -(trimethylsilyl)butanamide, H-00007 AT-Methyl- -(trimethylsilyl)acetamide, M-00330... [Pg.1321]


See other pages where Butanamides, 3- -3-methyl is mentioned: [Pg.2366]    [Pg.299]    [Pg.55]    [Pg.819]    [Pg.819]    [Pg.114]    [Pg.2002]    [Pg.1]    [Pg.220]    [Pg.939]    [Pg.218]    [Pg.494]    [Pg.250]    [Pg.261]    [Pg.289]    [Pg.619]    [Pg.668]    [Pg.668]    [Pg.668]    [Pg.1533]    [Pg.1533]    [Pg.1533]    [Pg.293]    [Pg.285]    [Pg.331]    [Pg.219]    [Pg.91]    [Pg.80]    [Pg.457]    [Pg.257]    [Pg.519]    [Pg.1021]    [Pg.1084]    [Pg.1211]    [Pg.1297]    [Pg.1326]   
See also in sourсe #XX -- [ Pg.514 , Pg.515 ]




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