Butanal oxime

A complicating factor in the metabolism of oximes arises from the possibility that they become reduced to the imine (RR C=NH) prior to hydrolysis, thus releasing NH3 rather than hydroxylamine (H2N-OH) as the primary metabolite. Evidence for this indirect pathway of hydrolysis comes from a study of the effect of a variety of selective enzyme inhibitors on the metabolism of butanal oxime (11.72) in rats [105]. 

Dehydration of oximes to form nitriles is, again, a rare but intriguing reaction. It has, indeed, been demonstrated that cytochrome P450 (see Chapt. 3 in [50]) is able to transform butanal oxime (11.103, R = H, R = Pr, Fig. 11.14, also 11.72) to butanenitrile by a Beckmann-type dehydration [105] [133]. The reaction is inhibited by the presence of 02, and is catalyzed by cytochrome P450 in its reduced (ferrous) state. 

Dix KJ, Coleman DP, Fossett JE et al. (2001) Disposition of propargyl alcohol in rat and mouse after intravenous, oral, dermal and inhalation exposure. Xenobiotica 31 357-375 Mathews JM, Black SR, Burka LT (1998) Disposition of butanal oxime in rat following oral, intravenous and dermal administration. Xenobiotica 28 767-777 Okuyama Y, Momota K, Morino A (1997) Pharmacokinetics of Prulifloxacin. Arzneim Forsch/Drug Res 47 276-284 Simonsen L, Petersen MB, Benfeldt E, Serup J (2002) Development of an in vivo animal model for skin penetration in hairless rats assessed by mass balance. Skin Pharmacol Appl Skin Physiol 15 414 124... 

Butal Butaldehyde Butalyde Butanal n-Butanal. Seen-Butyraldehyde Butanal oxime. See m-Butyraldehyde oxime... 

Butadiene/styrene polymer 1,3-Butadiene/styrene polymer Butadiene/styrene resin 1,3-Butadiene/styrene resin Butadiene/styrene rubber. See Styrene/butadiene polymer Butadiene. See Diacetyl Butal Butaldehyde Butalyde. Seen-Butyraldehyde Butamben. See Butyl PABA Butanal n-Butanal. See n-Butyraldehyde Butanal, 2-ethyl-. See 2-Ethylbutyraldehyde 1-Butanal, 3-methyl-. See Isovaleraldehyde Butanal, 2-methyl-. See 2-Methylbutyraldehyde Butanal, 3-(3-(1-methylethyl) phenyl)-. See Isopropylphenylbutanal Butanal oxime. See m-Butyraldehyde oxime Butanamide, 2-bromo-3,3-dimethyl-N-(1-methyl-1-phenylethyl)-. See Bromobutide Butanamide, 2-(4-chloro-2-nitrophenyl) azo)-N-(2,3-dihydro-2-oxo-1H-benzimidazo-5-yl)-3-oxo-. See Pigment orange 36 Butanamide, 2-((4-chloro-2-nitrophenyl) azo)-n-(2-methoxyphenyl)-3-oxo-. See Pigment yellow 73... 

Synonyms Butanal oxime Butyraldehyde oxime n-Butyraldehyde oxime Butyraldoxime n-Butyraldoxime... 

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