Buprenorphine hydrochloride

In October 2002, the FDA approved two new medications for treating opiate addiction, both developed by Reckitt Benckiser Pharmaceuticals. The new drugs, Subutex (buprenorphine hydrochloride) and Suboxone tablets (buprenorphine hydrochloride and naloxone hydrochloride) contain buprenorphine, a partial opioid agonist. Like methadone, buprenorphine binds to the brain s opioid receptors, but produces significantly reduced pleasurable effects than heroin. 

Suboxone tablets (buprenorphine hydrochloride and naloxone hydrochloride)... 

Drugs that may interact with buprenorphine hydrochloride include barbiturate anesthetics, benzodiazepines, CNS depressants, CYP3A4 inducers and inhibitors, and MAOIs. 

Buprenorphine, the other option for transdermal application on account of its potency, is more difficult to apply dermally in therapeutic doses (Roy et al., 1994 Grond et al., 2000). A surrogate parameter for skin penetration, provided the other prerequisites are fulfilled (Fig. 7), is the melting point of the active substance. With buprenorphine base this is 209°C and about 260°C for buprenorphine hydrochloride, compared with, for example, 83°C for fentanyl base and 150°C for fentanyl dihydrogen citrate. The DDS developer LTS devised a technical solution for reliable transdermal buprenorphine administration in the form of a matrix patch (Fig. 9). 

As nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate ALPE, the administration of NSAIDs should be avoided even after onset. When patients require analgesic agents, synthetic opioid agonist/antagonist analgesics (pentazocine hydrochloride or buprenorphine hydrochloride) should be administered. 

Watanabe, K., Yakou, S., Takayama, K., Isowa, K., and Nagai, T. (1996), Rectal absorption and mucosal irritation of rectal gels containing buprenorphine hydrochloride prepared with water-soluble dietary fibers, xanthan gum and locust bean gum,/ Controlled Release, 38,29-37. 

Infra-red Spectrum. Principal peaks at wavenumbers 1320,1077, 1503,1155,1120,947 (buprenorphine hydrochloride, KCl disk). 

Buprenorphine Hydrochloride, Buprenorphine h -drochloride, 21 -cyclopropyl-7or- (S)-l -hydroxy-1.2.2-tti-... 

A. A. Alwarthan and A. Townshend, Chemiluminescence Determination of Buprenorphine Hydrochloride by Flow Injection Analysis. Anal. Chim. Acta, 185 (1986) 329. 

Mixed Agonist/Antagonists (-)-Buprenorphine Hydrochloride (Buprenex)... 

Soly/pH method Buffer solutions with pH values ranging between 6 and 13 were prepared. Powdered buprenorphine hydrochloride was added in excess of solubility to 3 ml of each buffer solution. The solutions were vortexed for 30 min and maintained at room temperature, 23.0 0.3 °C overnight. The solutions were filtered dirou 100 um MUlipore filters aided by reduced pressure. The clear filtrate was appropriately diluted and analysed by HPLC using fluorescence detection. Calibration curves were prepared simultaneously."... 

Temgesic Sublingual Tablets (Buprenorphine hydrochloride). Schering-Plough Ltd. UK Summary of product characteristics, April 2004. 

Buprenorphine Hydrochloride Injection. Bedford Laboratories. US Prescribing information, August 2004,... 

Buprenorphine Hydrochloride Injection. Bedford Laberatories. US Prescribing informaticn, At ust 2004. 

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