Budesonide ointment

Melt hard paraffin, white wax, and hydrogenated castor oil in the fat-melting vessel at 100°C and maintain this temperature for 20 minutes. Then transfer this melted mass to the manufacturing vessel preheated to 85°C through 0.150 mm. Cool to 33°C while stirring. 

Disperse budesonide with liquid paraffin at 33°C use homogenizer to get homogeneous suspension. 

Transfer the dispersion from step 2 to the ointment base from step 1 in the manufacturing vessel while stirring. Homogenize well to obtain a homogeneous ointment containing the stated amount of budesonide per 100 g ointment. 

Mix and heat items 1-7 to 75°C. Cool slowly with stirring. 

Add item 1 to water slowly, agitating with extensive shear force until smooth. 

---

Budesonide is also given by inhalation as a nebulized solution in the management of childhood croup. It is also used topically in various skin diseases as a cream or ointment... 

---