Hakea gibbosa

The term bioadhesion ean be defined as the ability of a material (synthetic or natural) to stick (adhere) to a biological tissue for extended periods of time [27]. The phenomenon of bioadhesion can be visualized as a two-step process. The first step involves the initial contaet between polymer and the biological tissue. The second step is the formation of seeondary bonds due to noncovalent interactions. The strength of bioadhesion (expressed as the foree of detachment) for a novel oligosaccharide gum Hakea Gibbosa) contained in a buccal tablet developed by Alur et al. [28,29]... 

Due to its mucoadhesive and sustained-release properties, hakea gum (HG), obtained from the shrub Hakea gibbosa (Sm.) Cav. (Proteaceae), is used for the formulation of some buccal tablets containing chlorpheniramine maleate [242,243] or calcitonin [243]. Flat-faced Cutina-coated core tablets containing either 22/32 mg of HG, 25/40 mg of chlorpheniramine maleate and sodium bicarbonate/tartaric acid (1 1.5 molar ratio) were obtained by direct compression technique [243]. Also, an improved trans-buccal delivery system for therapeutic polypeptides obtained using direct compression technique supposes flat-faced Cutina-coated core tablets containing either 12/32 mg of HG and 40 pg (200 lU) of salmon calcitonin [244]. 

Alur HH, Father SI, Mitra AK, Johnston TP. Evaluation of the gum from Hakea gibbosa as a sustcuned-relecise cuid mucoadhesive component in bucccd tablets. Pharm Dev Technol. 4 (3) 347-358,1999. 

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