Bruceoside cytotoxicity

Fukamiya N, Okano M, Miyamoto M (1992) Antitumor Agents, 127. Bruceoside C, a New Cytotoxic Quassinoid Glucoside and Related Compounds from Brucea javanica. J Nat Prod 55 468... 

Bruceosides D (98), E (99), and F (100) show selective cytotoxicity in the leukemia and non-small cell lung, colon, CNS, melanoma, and ovarian cancer cell lines with log GI50 values in the range of-4.14 to -5.72 [46],... 

In recent literature [101] the synthetic compound 3,15-di-O acetylbruceolide (230), a derivative from bruceoside showed a potent in vitro antimalarial activity against Plasmodium falciparum equivalent to that of chloroquine (225) [102] and also a potent in vivo activity against Plasmodium berghei in mice, with low cytotoxicity against mouse mammary tumor, representing a model in the same host. 

Three new quassinoid glucosides, bruceoside-D (37), -E (38), and -F (39) were isolated from the same plant, and their structures were elucidated by spectral evidence and chemical transformation to known compounds. Bruceoside-D (37), -E (38), and -F (39) were evaluated for cytotoxicity in the NCI s in vitro human tumor cell line panel, which included 58 cell lines representing nine cancer types. These compounds showed selective cytotoxicity in cell lines of leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer, and breast cancer. The log GI50 values (log concentration which reduced cell growth to 50%) ranged from >-4 to -5.72, as shown in Table 2 [18]. 

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