Broussonetia kazinoki

M. Shibano, S. Kitagawa, and G. Kusano, Studies on the constituents of Broussonetia species. I. Two new pyrrolidine alkaloids, broussonetines C and D, as (l-galactosidasc and P-mannosidase inhibitors from Broussonetia kazinoki SIEB., Chem. Pharm. Bull., 45 (1997) 505-508. 

Broussonetia kazinoki Siebold Zucc. is a deciduous tree growing to 4.5 m that flowers in August. It occurs in mainland China, Japan, and Korea [1]. The plant requires well-drained soil but can grow in... 

The bioactive secondary metabolites reported from Broussonetia kazinoki can be classified into major two groups, alkaloids and flavonoids (Table 1), Fig. (1). The Kusano group at Osaka University of Pharmaceutical Sciences in Japan reported over 20 pyrrolidine alkaloids, broussonetines A-H, K-M, O-T, V-X, and Mi, and broussonetinines A and B, four pyrrolidinyl piperidine alkaloids, broussonetines I, J, Ji, and J2, two pyrroline alkaloids, broussonetines U and U, and one pyrrolizidine alkaloid, broussonetine N, from hot water extracts of B. kazinoki [16-24]. As shown in Table 1, some of these alkaloids exhibited strong... 

Table 1. Bioactive Compounds from Broussonetia kazinoki...

Kazinol B (phenolic extract) Broussonetia kazinoki, B. papyrifera (paper mulberry) (Moraceae) COX [PA (AA-induced)J... 

R, 3R, 5S, 8/ )-l,2-dihydroxy-3-hydroxymethyl-5-[(l/ )-l, 10-dihydroxy-6-oxo-decyl]-pyrrolizidine (Broussonetine N) Broussonetia kazinoki (Moraceae) branches ... 

Figure 3. Polyhydroxylated pyrrolidine alkaloids and derivatives isolated from Broussonetia kazinoki.

During the winter season, Kozo plants(Broussonetia kazinoki) are cut... 

C, sH33N06, Mr 359.46, oil, [ajp -l 17.5° (CH3OH). A potent inhibitor (ICso<50 nM) of jS-glucosidase, ga-lactosidase, and / mannosidase, isolated from the mulberry Broussonetia kazinoki (Moraceae). It is a lead structure for therapeutics against diabetes, cancer, and AIDS. 

Isoprenylated Spiro-compound from Broussonetia kazinoki Sieb. Heterocycles 24, 2141 (1986). 

Kato, S., Y. Hano, T. Fukai, Y. Kosuge, and T Nomura Kazinol P, a Novel Isoprenylated Spiro-Compound from Broussonetia kazinoki Sieb. Heterocycles, 24, 2141 (1986). 

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