Bronchoalveolar lining fluid

Juillerat-Jeanneret L, Aubert JD, Leuenberger P (1997) Peptidases in human bronchoalveolar lining fluid, macrophages, and epithelial cells Dipeptidyl (amino)peptidase IV, aminopeptidase N, and dipeptidyl (carboxy)peptidase (angiotensin-converting enzyme). J Lab Clin Med 130(6) 603—614. 

Bronchoalveolar lavage fluid (BALF) is presently the most common way of sampling components of the epithelial lining fluid and provides the most accurate reflection of pulmonary airway protein composition. Proteomic studies of BALF have already been published and have contributed to a better knowledge of the lung structure at the molecular level and the study of lung disorders at the clinical level [23]. 

Dumotier P, De Vuyst P, Strauss P, et al. 1990. Asbestos bodies in bronchoalveolar lavage fluids of brake lining and asbestos cement workers. Br J Ind Med 47 91-98. 

In 17 patients aged over 18 years with severe acute community-acquired pneumonia trovafloxacin concentrations were persistently high in the sputum, bronchial secretions, bronchoalveolar lavage fluid, and epithelial lining fluid, with no significant difference between these compartments (16). The authors proposed that measurement of sputum concentrations could be used to monitor the outcome of treatment. 

Beclometasone dipropionate is the most widely dispensed inhaled anti-inflammatory agent for astfunatic human patients. Inhaled beclometasone dipropionate reduces inflammatory cell populations in bronchoalveolar lavage fluid, controls clinical signs of airway obstruction and improves parameters of pulmonary function in human asthmatics. Consequently, aerosolized beclometasone dipropionate is the first line of therapy for mod-erate-to-severe allergic airway disease in human patients. Aerosolized beclometasone does not cause adrenal suppression in asthmatic human patients at therapeutic dosages (800-1600 xg/day) and initiation of beclometasone therapy as a replacement for systemic corticosteroid administration permits recovery of the hypothalamic-pituitary-adrenal axis (Barnes et al 1998). 

Kadota, J., Ishimatsu, Y., Iwashita, T., Matsubara, Y., Kohno, S., Tateno, M., and Ishihara, R. (2(X)0). The ketolide antimicrobial, telithromycin (HMR 3647), achieves high and sustained concentration in alveolar macrophages and bronchoalveolar epitherial lining fluid in healthy Japanese volunteers. Presented at 40th Intersci. Conf. Antimicrob. Agents Chemother. (Sept. 17-20, Toronto). Abstr. No. 2143. 

The bronchospasm that occurs immediately after aeroallergen inhalation in allergic asthmatic subjects is at least partly an IgE-mediated immediate hypersensitivity reaction (1). At least two lines of evidence support this mechanism for the early asthmatic response. Eirst, pretreatment with an anti-IgE monoclonal antibody attenuates the early phase response in asthmatic subjects (Fig. 1) (2,3). Second, analysis of bronchoalveolar lavage fluid collected immediately after air-... 

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