Bromide Inhalation Solution

Atrovent inhalation solution is administered by oral inhalation with the aid of a nebulizer. It contains ipratropium bromide 0.02% (anhydrous basis) in a sterile, isotonic 

---

Rx Albuterol sulfate and ipratropium bromide inhalation solution ... 

Inhalation solution 0.5 mg ipratopium bromide and 3 mg albuterol sulfate (equiv. to 2.5 mg albuterol base) DuoNeb (Dey)... 

Both bromides have skjn-irritant and lachrymatory properties therefore keep the crystals or their solutions from the skin and avoid inhaling the vapour of hot solutions, or of mixtures in hot water. 

Anticholinergics Atrovent (Boehringer Ingelheim) Ipratropium bromide Solution for inhalation 0.02% (500 pg/vial). In 25 unit dose vials per foil pouch. Preservative free... 

Note Highly polar solvent sweet, ethereal odor soluble in water flammable, burns with a luminous flame highly toxic by ingestion, inhalation and skin absorption miscible with water, methanol, methyl acetate, ethyl acetate, acetone, ethers, acetamide solutions, chloroform, carbon tetrachloride, ethylene chloride, and many unsaturated hydrocarbons immiscible with many saturated hydrocarbons (petroleum fractions) dissolves some inorganic salts such as silver nitrate, lithium nitrate, magnesium bromide incompatible with strong oxidants hydrolyzes in the presence of aqueous bases and strong aqueous acids. Synonyms methyl cyanide, acetic acid nitrile, cyanomethane, ethylnitrile. 

Benzalkonium chloride at concentrations greater than 0.005 mg/ml causes histamine release from mast cells in vitro. At a concentration of 0.03 mg/ml an excess of 90% of the histamine content is released (5). This is in the range of the minimum concentration of benzalkonium chloride recommended as a disinfectant (0.025 mg/ml). Inhalation of benzalkonium chloride nebulizer solution causes concentration-related falls in FEVi in patients with asthma (6). Benzalkonium chloride 0.3 mg also causes a temporary increase in airway reactivity to histamine. This amount of benzalkonium chloride is similar to that in a 2.5 mg dose from a multidose vial of salbutamol (7). Ipratropium containing benzalkonium chloride 0.25 mg/ml causes bronchoconstriction in a proportion of patients with asthma. BronchodUatation is seen when 2 ml (0.5 mg) of preservative-free ipratropium bromide solution is inhaled (8). Benzalkonium chloride 0.1 mg/ml does not alter the bronchodUator effect of salbutamol. The difference between salbutamol and ipratropium may be the lower concentration of benzalkonium chloride in the salbutamol solution (0.1 versus 0.25 mg/ml) and the greater potency and more rapid onset of the bronchodilator response to salbutamol (9). Individual case reports suggest that... 

Caution. Cyanogen bromide (BrCN) (5 M acetonitrile solution or solid) is corrosive, volatile (fumes in air), and toxic. Use safety gloves and goggles, avoid inhalations of vapors, and conduct all operations in a well-ventilated hood far from ignition sources. 

Storage and Handling Ethidium bromide should be handled in the laboratory using the "basic prudent practices" described in Chapter 5.C. Because of its mutagenicity, stock solutions of this compound should be prepared in a fume hood, and protective gloves should be worn at aU times while handling this substance. Operations capable of generating ethidium bromide dust or aerosols of ethidium bromide solutions should be conducted in a fume hood to prevent exposure by inhalation. 

---