Bromazepam

Abuse of the other benzodiazepines is typified by bromazepam abuse, which is in third place in the abuse statistics. It is consumed in similarly increasing amounts by all patient groups (drug, medicament, and alcohol abusers). Although a few individual dose rates reach 100 mg, most users do not attract attention or are detected too late because of low dose rates. Drug users also combine the substance with other benzodiazepines. 

Trade Name Manufacturer Country Year Introduced 

N-ol3romobenzyl-N,N-dimethylamina (lOOg) and ethyl p-toluenesulfonate (94 g) were mixed and warmed to 50°-60°C after standing for either (s) a minimum of 96 hours at 15°-20°C or (/ ) a minimum of 18 hours at 50°-60°C and cooling to room temperature, a hard, crystalline mass was formed. Recrystallization of this product from acetone (2.0 ml/g of crude solid), followed by filtration and drying to 60°C gave N-o-bromobenzyl-N-ethyl-N, N-dimethylammo-nlum p-toluenesulfonate as a white, crystalline solid, MP 97°-99°C. For this procedure it was necessary that the reactants were substantially colorless and of a high purity. 

Chemical Name 7-bromo-1,3-dihydro-5-(2-pyridinyl)-2H-1,4-benzodiazepin-2-one Common Name — 

145 kg of 2-(2-amino-5-bromobenzoyl)-pyridine, was dissolved in 2.0 liters of glacial acetic acid. The resultant solution was placed in a 3 liter, 3-necked, round bottom flask fitted with a stirrer, thermometer and dropping funnel. The system was protected by a drying tube filled with anhydrous calcium chloride. To the solution, with stirring at room temperature, were carefully added 46.7 ml of bromoacetyl bromide. After the addition was 

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Benzodiazepines, ie, the hiU BZR agonists, are prescribed for anxiety, insomnia, sedation, myorelaxation, and as anticonvulsants (97). Those benzodiazepines most commonly prescribed for the treatment of anxiety disorders are lorazepam (19), alprazolam (20), diazepam (21), bromazepam (22), chlorazepate (23), and oxazepam (24). These dmgs together represent about 70% of total... 

Timolol maleate a-Bromoacetophenone Nomifensine maleate Bromoacetyl bromide Bromazepam Cephapirin sodium Clonazepam Flunitrazepam 5-Bromoacetyl salicylamide Labetalol HCI m-Bromoanisole Tramadol HCI p-Bromoanisole Cyclofenil Bromobenzene... 

C7HSN2 1885-29-6) see Bromazepam Tacrine 1,8-anthraquinonedisulfonic acid (C 4HsOjS2 82-48-4) see Dithranol anthrone... 

C 7H jBrN3 65676-22-4) see Brompheniramine bromo(2-phenylethyl)magnesium (CjH BrMg 32 77-S9-2) see Enalapril (4-bromophenyl)hydrazine monohydrochloride (C4HgBrClN2 622-88-8) see Bromazepam... 

Note Separate potassium iodide and starch solutions can also be used successively [2], The detection limits for bromureides are 40 to 200 ng substance per chromatogram zone [7, 10]. Bromopride, bromazepam, bromhexine and bromocriptine do not reac [10]. 

Bromisoval (h/ f 15-20) yielded dark brown chromatogram zones on a light brown background. Bromopride, bromazepam, bromhexine, bromocriptine, caryophyllene epoxide and rose oxide did not react. 

Other applications include bioequivalent measurements of bromazepam, an anticonvulsant, in human plasma. The lower limit of quantitation (LLOQ) was 1 ng/mL (Gongalves et al. 2005). Kuhlenbeck et al. (2005) studied antitussive agents (dextromethorphan, dextrophan, and guaifenesin) in human plasma LLOQ values were 0.05, 0.05, and 5 ng/mL, respectively. Other compounds studied were nucleoside reverse transcriptase inhibitors, zidovudine (AZT) and lamivudine (3TC) (de Cassia et al. 2004) and stavudine (Raices et al. 2003) in human plasma, and paclitaxel, an anticancer agent, in human serum (Schellen et al. 2000). 

Gon9alves J.C.S. et al., 2005. Online solid-phase extraction coupled with high-performance liquid chromatography and tandem mass spectrometry (SPE HPLC-MS-MS) for quantification of bromazepam in human plasma. Ther Drug Monit 27 601. 

Gerhard U, Hobi V, Kocher R, Konig C. (1991). [Acute sedative effect of an herbal relaxation tablet as compared to that of bromazepam]. Schweiz Rundsch Med Prax. 80(52) 1481-86. 

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