Cimetidine Bromazepam

Noninterfering amiloride, acebutolol, acenocoumarol, acetaminophen, aspirin, allopuri-nol, ambroxol, amoxicillin, atenolol, bendroflumethiazide, benzbromarone, bezafibrate, biperiden, bisacodyl, bromazepam, butizide, captopril, cimetidine, ciprofloxacin, clobu-tinol, clonidine, cotinine, diazepam, diclofenac, digitoxin, digoxin, dihydrocodeine, dihy-droergotamine, diltiazem, doxepin, doxycycline, enalapril, erythromycin, fenoterol, furosemide, glibenclamide, heparin, h3qjoxanthine, ibuprofen, indomethacin, isosorbide... 

Ochs HR, Greenblatt DJ, Friedman H, Burstein ES, Locniskar A, Harmatz JS, Shader RI. Bromazepam pharmacol etics influence of age, gender, oral contraceptives, cimetidine, and propranolol. Clin Pharmacol Ther 9ZT) 41,562-70. 

The combined serum level of diazepam and its active metabolite, des-methyldiazepam, was found to be increased by 75% in 10 patients who took cimetidine 300 mg four times daily for 2 weeks, but reaction times and other motor and intellectual tests remained unaffected. Other reports describe a rise in the plasma levels and/or AUC of diazepam (associated with increased sedation in one report ) due to cimetidine, and generalised incoordination has also been described in one individual. Cimetidine also raises the serum levels of adinazolam, alprazolam, chlordiazepoxide, clobazam, clorazepate, flu-razepam, nitrazepam, and triazolam, > > > and reduces the clearance of bromazepam. ... 

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