Broad-spectrum agents

Amoxicillin is first-line treatment for acute bacterial sinusitis. It is cost effective in acute uncomplicated disease, and initial use of newer broad-spectrum agents is not justified. The approach to treating acute bacterial sinusitis is given in Table 44-9. Dosing guidelines are given in Table 44-10. 

The SSRIs are considered broad-spectrum agents in the treatment of PTSD. In a seminal study leading to sertraline s FDA indication for the treatment of adult PTSD, Brady et al. (2000) demonstrated effectiveness over placebo in 94 subjects treated with sertraline (versus 93 with placebo) in three of four primary outcome measures. 

In a typical example of the s)mthesis of one of these broad-spectrum agents, the cefamandole intermediate (20-2) is first acylated with the protected thiazole acid chloride (21-5) to give the amide (22-1). Removal of the protecting group by reaction of that intermediate with thiourea can be envisaged as involving an initial displacement of chlorine on the side chain by sulfur to form an intermediate such... 

An additional consideration is the role of excessive prescription of broad-spectrum antibacterial drugs in the generation and proliferation of resistant organisms. While it may seem best for the individual, at the time, to prescribe the most potent, broad-spectrum, agent possible such practice is likely to disadvantage future patients and the wider community. 

Differential selective or broad spectrum agents include nematacicides (Table 17.9), acaracides, ovicides, molluscicides (Table 17.10), algicides (Table 17.11), bactericides... 

Neu, H.C., Quinolones as broad-spectrum agents, in The 4-Quinolones, G.C. Crumplin (Ed), Springer-Verlag, New York, pp 1-13,1990... 

The sulfated compounds MM 13902 (3, n = 0) and MM 17880 (4) are also broad-spectrum agents, but not as potent as thienamycin and all lack any significant activity against Pseudomonas (73). Many carbapenems are excellent inhibitors of isolated P-lactamases, particulady the olivanic acid sulfoxide MM 4550 (3, n = 1) (3). The possible mechanism of action of the carbapenems as inhibitors of P-lactamases has been discussed in some detail (74). Other carbapenems such as PS-5 (5) (75), the carpetimycins (76), asparenomycins (77), and pluracidomycins (8) are all highly active as antibiotics or P-lactamase inhibitors. The parent nucleus itself (1, X = CH2) is intrinsically active, but chemically unstable (9). 

Antibiotic broad-spectrum agent inhibits protein synthesis (SOS) uses restricted to backup drug for bacterial meningitis, infections due to anaerobes, salmonella. Tox reversible myelosuppression, aplastic anemia, gray baby syndrome. 

Once very widely used, tetracyclines have faded considerably in popularity because of widespread resistance and the introduction of newer broad-spectrum agents, such as amoxicillin with clavulanate. Research, however, continues, and novel analogues can be expected as indicated by the recent U.S. FDA approval of tigecycline, the first of a new class of tetracyclines referred to as the glycylcyclines. 

Select the proper detector for the perceived threat. This will usually be a tape or paper detector for broad-spectrum agent detection (Figure S5.8). You must be familiar with the abilities of the detector and what agents it will detect. Because many of these detectors are heat and moisture sensitive, they should be stored in a dry environment at room temperature. 

Interest and need is especially high with rhinoviruses. There are so many strains of rhinoviruses that chemotherapy would appear to be the method of choice for prevention or treatment. An efficient system for plaguing most rhinovlrus strains,has been developed utilizing a special line of HeLa cells.Because of the need of a broad-spectrum agent for rhinoviruses, it has been suggested to screen in tissue culture teste with mixtures of strains of rhinoviruses. ... 

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