Broad biological potential

Among the fused aminopyrans, 2-amino-4H-chromenes draw especial attention due to their broad biological potential. Benzochromenes 143 in vitro inhibit the synthesis of metalloproteases that destroy cartilage tissues in rheumatoidal arthritis and osteoarthritis. Moreover, 143 inhibit proliferation of mice spleen cells (95BML2783). 

Broad biological potential of enantiopure 1,2-dihydroquinolines prompted the recently reported organocatalytic, asymmetric Petasis reaction, catalyzed by chiral biphenols [31]. Since it was observed that chiral biphenol derivatives XXVI-XX-VIII serve as proficient catalysts for asymmetric reactions involving boronates [32, 33], the authors postulated that they could be used as ligands in multi-component condensation reactions, and the Petasis reaction in particular. 

As a result of their broad biological potential, substituted benzofurans are of high interest in present-day organic chemistry. They are of additional interest due to the fact that they are... 

In this review we describe the basic principles and application potential of crystalline bacterial cell surface layers (S-layers), a self-assembly system optimized through time, selection, and evolution as a unique nanostructure [3-6]. S-layers are fascinating model systems for studying the dynamic process of assembly of a biological supramolecular structure [7]. The broad application potential of S-layers is based on the specific intrinsic features of the monomolecular arrays composed of identical protein or glycoprotein subunits. Since S-layers are peri-... 

Once again, this volume of "The Alkaloids Chemistry and Biology is comprised of four quite different chapters, from three different continents, on mechanisms of c)dotoxic action, the calystegines, strychnine synthesis, and substituted quinoline alkaloids. This diversity reflects the need to see alkaloids as a class of natural product having tremendous biological potential and of continued broad scientific interest. 

Today the chemical industry is involved in a broad spectrum of manufacturing processes tliat range from biological preparations to plastics and e.vplosives. Altliough the basic plans and designs for tliese processes may be similar, each individmil plant will have its own unique set of potential hazards. 

Although pharmacology still relies heavily on small chemical substances, biologicals like recombinant proteins, cell-based therapies, and gene-therapy approaches have great potential for the treatment of broad spectrum of diseases. Therefore, the focus of modem pharmacology should shift towards these innovative therapies. 

Most known cannabimimetics today have very broad effects on organ systems, several of which are still not completely delineated. The ubiquitous pharmacology of cannabimimetics is one of the reasons for the failure, thus far, of the clinical application of these drugs to reach its full potential. The sections that follow summarize the effects of cannabinergics on the various physiological systems and the possible therapeutic uses that may arise from these biological activities. 

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