Breasts bicalutamide

Bicalutamide 50 mg/day Gynecomastia Hot flushes Gastrointestinal disturbances (diarrhea) Liver function test abnormalities Breast tenderness... 

The adverse effects of antiandrogens are gynecomastia, hot flushes, GI disturbances, liver function test abnormalities, and breast tenderness. GI disturbances consist of diarrhea for flutamide and bicalutamide and nausea or constipation for nilutamide. Flutamide is also associated with methemoglobinemia, whereas nilutamide causes visual disturbances (impaired dark adaptation), alcohol intolerance, and interstitial pneumonitis. 

Antiandrogens include steroids, such as cyprotcronc acetate, and non-steroidal agents, such as bicalutamide, fluta-mide, and nilutamide. They have different endocrine effects and therefore different adverse effects (1). Cyproterone acetate tends to result in a loss of sexual interest and erectile dysfunction, whereas most men experience this only moderately or not at all during nonsteroidal treatment. The most common adverse effects of the non-steroidal agents are gynecomastia and breast... 

In a series of studies from Italy an attempt was made to determine whether giving anastrozole 1 mg/day and/or tamoxifen 20 mg/day could prevent gynecomastia and breast pain due to bicalutamide 150 mg/day (72). In a 48-week double-blind study tamoxifen reduced the symptoms but anastrozole did not. 

In one case a man taking bicalutamide developed gynecomastia, which proceeded to breast cancer (76). 

Chianakwalam C.I, McCahy P, Griffiths N.J. A case of male breast cancer in association with bicalutamide-induced gynaecomastia. Breast 2(X)5 14 163—4. 

Bicalutamide is approved for combination therapy with ui LH-RH analogue for treatment of advanced prostate cancer. Its response is measured by decreased prostatc-specific antigen levels. Adverse reactions include gynecoma.stia. breast pain, and inhibition of spermatogenesis. There is an mtetaction with coumadin. " ... 

Treatment of prostate cancer with bicalutamide is valuable, but it tends to cause gynecomastia and breast pain. Tamoxifen can be used to attenuate these complications, but there has been some doubt about... 

Breasts Here, we present a case of gynaecomastia induced by bicalutamide. 

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