Breast tumors cell adhesion

Mgat5 l breast tumor cells removed from the mice and placed in tissue culture showed impaired focal adhesion formation in low serum conditions (Figure 3). By activating c-Sre/FAK, Shc/RAS and PI3K, the PyMT protein contributes to the reorganization of cytoskeletal structures and turnover of focal-adhesion contacts... 

A transcription factor gene nm23 may be a suppressor gene for metastasis"" and the cell-cell adhesion molecule E-cadherin may suppress tumor invasion in some kinds of breast cancer. The VHL (van Hippel-Lindau cancer syndrome) suppressor protein is defective in the majority of kidney cancers. It normally binds to the elongin complex, a DNA-binding complex that functions in control of transcription. ... 

Resveratrol has been shown to inhibit proliferation, induce differentiation, and enhance the expression of adhesion molecules (GDI la, GDI lb, GDIS, GD54) in a variety of myeloid leukemia cell lines [144]. The inhibitory effect of resveratrol on cell survival and proliferation of human breast cancer cells was shown to be estrogen receptor dependent [145]. Other studies indicated that it was very effective in inhibiting growth of 4T1 breast cancer cells in culture but had little effect on 4T1 tumor cell growth in mice [146]. In stark contrast, resveratrol was tested against mammary tumors induced by 7, 12-dimethylbenz(a)anthracene (DMBA) in rats [147]. In this case, reductions in incidence, multiplicity, and latency period of tumor development were observed. Additional... 

Cowin P, Rowlands TM, Hatsell SJ (2005) Cadherins and catenins in breast cancer. Curr Opin Cell Biol 17 499-508 Crnic I, Strittmatter K, Cavallaro U et al (2004) Loss of neural cell adhesion molecule induces tumor metastasis by up-regulating lymphangiogenesis. Cancer Res 64 8630-8638... 

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