Elongin complex

Elimination reactions 526, 530, 677—690 beta, of cystine residues 85 conjugative 689 decarboxylative 689 facilitation by carbonyl group 681 of y substituent 746 of PLP-dependent enzymes 742 reversibility 690 Ellman s reagent 125,125s Elongation factor EF-Tu 558 Elongin complex 564... 

A transcription factor gene nm23 may be a suppressor gene for metastasis"" and the cell-cell adhesion molecule E-cadherin may suppress tumor invasion in some kinds of breast cancer. The VHL (van Hippel-Lindau cancer syndrome) suppressor protein is defective in the majority of kidney cancers. It normally binds to the elongin complex, a DNA-binding complex that functions in control of transcription. ... 

Kamuea, T., et al.. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev,... 

Fig. 6.2. The structures of SCF, Cul2-Elongin B-C, and Cul3-BTB/POZ ubiquitin E3 ligase complexes with the bound substrates and E2 enzymes.

Loneegan, K. M. et al. Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. 

Feldman, D. E., V. Thulasiraman, R. G. Ferreyra, and J. Frydman (1999). Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC. Mol. Cell 4, 1051-1061. 

Figure 3. SOCS ubiquitin ligase complex. SOCS1 forms an E3 ubiquitin ligase complex with elongins B and C, Cullin-2. The ubiquitinated substrate is subsequently recognized and degraded by the proteasome.

Stebbins CE, Kaelin WG, Paveletich NP. Structure of the VHL-elongin C-elongin B complex implications for VHL tumor suppressor function. Science 1999 284 455-461. 

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