Breast Estrogens

Contraindications Carcinoma of breast estrogen-dependent neoplasm history of or active thrombotic disorders, such as cerebral apoplexy, thrombophlebitis, or thromboembolic disorders hypersensitivity to progestins severe hepatic dysfunction undiagnosed abnormal genital bleeding... 

The chlorinated pesticides DDT and chlordecone are known to generate deleterious reproductive effects. In a bioassay of these and other chlorinated pesticides on cultured human breast estrogen-sensitive MCF7 cells, it was shown that dieldrin, toxaphene, and endosulfan have estrogenic properties comparable to those of DDT and chlordecone. When tested together, the mixture of the three pesticides induced estrogenic responses... 

Undiagnosed abnormal Prevention of benign breast Estrogenic side effects (nausea. ... 

In an in culture bioassay using human-breast estrogen-sensitive MFC7 cells to assess the estrogenicity of several pesticides, it was found that mixtures of the pesticides induced estrogenic responses at lower concentrations than those required for the single pesticides. The pesticides tested included DDT, chlordecone, dieldrin, toxaphene, and endosulfan [94],... 

For the purposes of this article, antiestrogens are compounds that counteract the biological activity of estrogens at the receptor level. In the late 1970s, there were no steroidal antiestrogens in widespread clinical use. Clomiphene [911 -45-5]( ) and tamoxifen/7(954(9-25 -/7(9) were nonsteroidal antiestrogens that had been employed for the treatment of female infertility and breast cancer, respectively. 

WS-7528 [132147-69-4][VI] a nonsteroidal estrogen, is an isoflavone which has been isolated from Streptomjces sp. No. 7528 and is an estrogen agonist. It inhibits [3ff]-estradiol binding to its receptor in rat uterine cytosol at an inhibitor for 50% of the rats tested (IC q) concentration of 5.7 nM. It also induces the growth of estrogen-dependent human breast cancer cell line MCE-7 (7). 

A stmcturally related series of phenyfiiydrazones resulted ia the selection of compound A-007 [2675-35-6] (DEKK-TEC)(37) for the treatment of hormone-dependent tumors. A-007 is an antiestrogen that, ia contrast to tamoxifen, demonstrated inhibitory activity both ia the presence and absence of estradiol ia ZR-75-1 estrogen-dependent human breast cancer cells, and afforded more protection than tamoxifen ia the 7,12-dimethylbenz[i7]anthracene... 

Estrogens coordinate the systemic response during the ovulatory cycle, including the growth and maintenance of the reproductive tract, pituitary, breasts, and other tissues. Estrogens are also responsible for maturation of the skeleton and development of female secondary sex characteristics when females enter puberty. The other important functions of estrogens include modulation of many metaboHc processes (76). 

Glucocorticoids have inhibitory (apoptotic) effects on lymphocyte proliferation and are used to treat leukemias and lymphomas. Estrogens (fosfestrol) are used to block the effect of androgens in prostate cancer. Progestogens (megestrol, medroxyprogesteroneacetate) have been useful for treating endometrial carcinoma, renal tumors, and breast cancer. 

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