Estrogen-dependent breast cancer

Flueggine A MCF-7 (human breast cancer) estrogen-dependant phenotype 60 4 pM... 

Contraindications History of thromboembohc disorders, deep venous thrombosis, cerebral vascular disease, myocardial infarction, liver cancer, estrogen-dependent cancer, breast cancer, undiagnosed abnormal genital bleeding, or suspected pregnancy. 

WS-7528 [132147-69-4][VI] a nonsteroidal estrogen, is an isoflavone which has been isolated from Streptomjces sp. No. 7528 and is an estrogen agonist. It inhibits [3ff]-estradiol binding to its receptor in rat uterine cytosol at an inhibitor for 50% of the rats tested (IC q) concentration of 5.7 nM. It also induces the growth of estrogen-dependent human breast cancer cell line MCE-7 (7). 

A stmcturally related series of phenyfiiydrazones resulted ia the selection of compound A-007 [2675-35-6] (DEKK-TEC)(37) for the treatment of hormone-dependent tumors. A-007 is an antiestrogen that, ia contrast to tamoxifen, demonstrated inhibitory activity both ia the presence and absence of estradiol ia ZR-75-1 estrogen-dependent human breast cancer cells, and afforded more protection than tamoxifen ia the 7,12-dimethylbenz[i7]anthracene... 

Breast cancer is cancer of the breast tissues. The major part of this cancer in women is dependent on the female sex hormones for their growth. An estrogen antagonist can therefore be used in the treatment of breast cancer to limit the growth of the tumor. 

TWADDLE G M, TURBOV J, LIU N, MURTHY s (1999) Tyrosine kinase inhibitors as antiprohferative agents against estrogen-dependent breast cancer cell line in vitro. JSurg Oncol. 70 ... 

YCUNG H J, DCERGE D R, KIMBERLY F A, ALLRED C D and HELFERICH W G (2002) Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Res 62,2474-77. 

HRT should not be prescribed to women with a history of or active thromboembolic disease, breast cancer or estrogen-dependent neoplasm, pregnancy, liver disease, or undiagnosed vaginal bleeding. It also should not be used for the prevention or treatment of cardiovascular disease, cerebrovascular disease, or dementia.11... 

Estrogen is more effective than any other therapy in relieving vasomotor symptoms, and all types and routes of systemic administration are equally effective in a dose-dependent fashion. If treatment can be tapered and stopped within 5 years, no evidence of increased risk of breast cancer is seen. 

Boyan BD, Sylvia VL, Frambach T, Lohmann CE1, Died J, Dean DD, Schwartz Z (2003) Estrogen-dependent rapid activation of protein kinase C in estrogen receptor-positive MCF-7 breast cancer cells and estrogen receptor-negative E1CC38 cells is membrane-mediated and inhibited by tamoxifen. Endocrinology 144(5) 1812—1824... 

The individual ability to produce estrogens becomes more relevant when analyzing estrogen-dependent diseases like osteoporosis and breast cancer. The incidence of breast cancer and fracture are inversely related. Cauley s data also illustrate this negative correlation (Cauley et al. 1996). 

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