Breast cancer Subject

Fig. 2.4 Survival of mice with the breast cancer subjected to treatment with test substanees...

Gas Chromatographic Determination of Urinary 17-Keto Steroids in Postoperative Breast Cancer Subjects Univ. Microfilms (Ann Arbor, Mich.) Order No. 67-8108, 101 pp. Diss. Abstr. 27B(12) 4237 (1967) CA 67 114040b... 

Two NKxr splice variants have been identified (Table 3). A NKxr splice variant having a very short C-terminal intracellular tail (7 instead of 96 amino acids), which has been expressed and characterized in recombinant systems (Fig. 1), was found to be expressed at higher level than the long isoform in breast cancer cells. As compared to the long receptor, the short NKxr isoform is less subjected to desensitization and internalization... 

In 1990, Vatten et al.51 in Norway subsequently reviewed data on breast cancer risk from a cohort of 14,593 women with 152 cases of breast cancer during a follow up of 12 years on subjects who were between 35 and 51 years old at the beginning of the study and between 46 and 63 years at the end. They reported no overall statistically significant correlation between breast cancer and coffee consumption, but when body mass index was taken into account, lean women who consumed >5 cups per day had a lower risk than women who drank two cups or less. In obese women, however, there was a positive correlation between coffee intake and breast cancer. In a 1993 study, though, Folsom and associates52 failed to find an association between caffeine and postmenopausal breast cancer in 34,388 women in the Iowa Women s Health Study, with a median caffeine intake of 212 mg/day in women who developed breast cancer and 201 mg/day for women who did not and in Denmark, Ewertz53 studied... 

As for tamoxifen, in the aforementioned studies by Mourits et al. (2002) on breast cancer patients analyzing the effects on subjective and psychosexual well-being, disturbed sleep (55% of patients) correlated with hot flashes and concentration problems. 

Mourits MJ, Bockermann I, de Vries EG, van derZee AG, ten Hoor KA,van derGraaf WT, Sluiter WJ, Willemse PH (2002) Tamoxifen effects on subjective and psychosexual wellbeing, in a randomised breast cancer study comparing high-dose and standard-dose chemotherapy. Br J Cancer 86 1546-1550... 

DFBcPh and its dihydrodiol were subjected to metabolism, and the extent of DNA binding in human breast cancer MCF-7 cells was assessed." The extent of DNA binding was then compared with that for BcPh and its dihydrodiol and the potent carcinogen BaP. The 1,4-DFBcPh series 2 (anti) DE-derived DNA adducts were also compared with those arising from intracellular oxidation of the dihydrodiol with subsequent DNA binding. These experiments showed that increased molecular distortion decreased metabolic activation to the terminal metabolites but the DE metabolites formed were the DNA-damaging species. 

Our study group consisted of 167 individuals, of whom 99 were healthy women controls and 68 breast cancer cases. The experimental group was comprised of women who had been diagnosed with breast cancer at the Department of Medical Oncology, Mersin University, Turkey. Controls were selected by taking age and sex variable into consideration. Genomic DNA from breast cancer patients and control subjects was analyzed by PCR-RFLP. 

J. Cancer 85 (1999) 596-600 E. M. Ward et al., Serum Organochlorine Levels and Breast Cancer A Nested Case-control Study of Norwegian Women, Cancer Epidemiol. Biomarkers. Prev. 9 (2000) 1557-67 D. Bagga et al., Organochlorine Pesticide Content of Breast Adipose Tissue from Women with Breast Cancer and Control Subjects, J. Natl. Cancer Inst. 92... 

In an abstract, Freudenheim et al. (1997) presented the results of a study conducted in western New York, United States, on 134 premenopausal and 181 postmenopausal cases of breast cancer and 356 population controls. Heavy alcohol intake was associated with an increased risk for premenopausal breast cancer (odds ratio, 3.5 95% CI, 1.3-9.2) among ADHj subjects but not among women with ADHj or ADH32-2 genotypes. This association was not observed for postmenopausal breast cancer. 

Because biochemical methods used in the 1970s required large amounts of the tissue for homogenization, the studies concentrated on breast cancer (Fig. 11.1) rather than on normal breast (Fig. 11.2/Plate 5E). It was not until the development of antibodies against ER, which would be effective for the fixed tissue of a small size subjected to antigen retrieval, that normal breast tissue began to be analyzed for ER. 

Kohlberger, P. D., Breitenecker, F., Kaider, A., Losch, A., Gitsch, G., Breitenecker, G., and Kieback, D. G. 1999. Modified true-color computer-assisted image analysis versus subjective scoring of estrogen receptor expression in breast cancer a comparison. Anticancer Res. 19 2189-2194. 

TAC of patients subjected to surgery (abdominal or breast cancer operations) showed remarkable stability, showing small changes (increase or decrease) immediately after and 6 hr after surgery and normalizing 12 hr after surgery (M28). 

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