Huxley, Hugh

FIGURE 17.12 Electron micrograph of a skeletal muscle myofibril (in longitndinal section). The length of one sarcomere is indicated, as are the A and I bands, the H zone, the M disk, and the Z lines. Cross-sections from the H zone show a hexagonal array of thick filaments, whereas the I band cross-section shows a hexagonal array of thin filaments. (Photo courtesy of Hugh Huxley, Brandeis University)... 

A.F. Huxley s 1957 Theory Further Structural Approaches Hugh Huxley s 1969 Theory Transient Mechanical Properties Velocity Transients Tension Transients... 

The muscle fibrils are embedded in sarcoplasm, each individual fibril showing the banding pattern of the whole fiber (Bowman, 1840). Myosin could be extracted from muscle with strong salt solutions. From the altered appearance of the bands after extraction it was suggested that this protein was a major component of the A bands (Kuhne,1864 Danilewsky, 1881). The localization of myosin in the A bands and of actin in the I bands was convincingly shown by Jean Hanson and Hugh Huxley (1954-1955) in electron micrographs of transected fibers and confirmed after selective extraction to remove myosin (Hasselbach, 1953 Hanson and H.E. Huxley, 1953-1955). 

Svensson, A. Bordas, J. Hughes, E.A. Mant, G. Radiation damage induced in free nucleotides and sulfur-containing amino-acids by monoenergetic X-rays. Chance, B., Deisenhofer, J., Ebashi, S., Goodhead, D.T., Helliwell, J.R., Huxley, H.E., lizuka, T., Kirz, J., Mitsui, T., Rubenstein, E., Sakabe, N., Schmahl, G., Stuhrmann, H.B., Wuthrich, K., Zaccai, G., Eds. Synchrotron Radiation in the Biosciences, 1994 721-729. 

Electron micrograph of a striated muscle sarcomere showing the appearance of filamentous structures when cross-sectioned at the locations illustrated below. (Electron micrograph courtesy of Dr. Hugh Huxley, Brandeis University.)... 

Electron micrograph of a longitudinal section of a skeletal muscle fiber showing a number of myofibrils. Muscle protein is an unusual example of a structural protein with enzymatic activity. (Courtesy of Dr. Hugh Huxley)... 

Hugh Huxley proposed the sliding filament model for muscular contraction. 

Figure 34.19. Thick Filament. (A) An electron micrograph of a reconstituted thick filament reveals the presence of myosin head domains at each end and a relatively narrow central region. (B) A schematic view shows how myosin molecules come together to form the thick filament. [Part A courtesy of Dr. Hugh Huxley.]...

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