Brain types

Hoffmann, A., et al. (1994). Carbohydrate structures of beta-trace protein from human cerebrospinal fluid evidence for brain-type N-glycosylation. J. Neurochem. 63, 2185-96. 

Matsuok, I., Maldonado, R., Defer, N., Noel, E, Hanoune, J. and Roques, B. Chronic morphine administration causes region-specific increase of brain type VIII adenylyl cyclase mRNA. Eur. J. Pharmacol. 268 215-216,1994. 

Chakrabarti A, Onaivi ES, Chaudhuri G, Cloning and sequencing of a cDNA encoding the mouse brain-type cannabinoid receptor protein, DNA sequence 5 385-388, 1995. 

K. Crystal structure of brain-type creatine kinase at 1.41 A resolution. Protein Sci., 8, 2258-2269 (1999)... 

Cholecystokinin (CCK) The tetrapeptide CCK causes more panic attacks when infused into patients with panic disorder than it does in normal volunteers, which suggests increased sensitivity of the brain type of CCK receptor, known as CCK-B. Unfortunately, in early investigations CCK-B antagonists did not appear to be effective for panic disorder. Nevertheless, agents with novel pharmacological mechanisms of action are sometimes evaluated for their potential antipanic actions by testing whether they can block CCK-induced panic attacks. 

Makover, A., Zuk, D., Breakstone, J., Yaffe, D., and Nudel, U., 1991, Brain-type and muscle-type promoters of the dystrophin gene differ greatly in structure, Neuromuscul Disord, 1, pp 39-45. 

Brain-type TLSP Prostate-type variant is located 282 bp downstream end of brain-type specific noncoding exon 1 [263]... 

Creatine kinase (CK) is a dimeric enzyme with two subunits, M (muscle type) and B (brain type). Three isozymes are distinguished CK 1-BB (brain), CK 2-MB (heart), and CK 3-MM (skeletal muscle). The total CK activity found in skeletal muscle is almost entirely of the CK 3 type, that in heart muscle is 15-20% CK 2 and the remainder CK 3, and that in brain is all CK 1. In the human being, the only significant source of blood CK 2 is the heart muscle. Because the intact blood-brain barrier appears to be impermeable to CK, the occurrence of CK 1 in blood is unlikely. The total serum CK activity in healthy individuals is almost exclusively that of CK 3. 

Seatter, M., Kane, S., Porter, i.., Arbuckic, M., Melvin, D, and Gould, G, (1997), Structure-function studies of the brain-type glucose transporter, GLUT3. Biochemisiry 36, 6401-6407. 

During the last half century, Japanese encephalitis has been recognized as an important arboviral disease in man in Japan, China, Korea, Thailand, India, Nepal, Sri Lanka, and Vietnam. In 1954, Japanese encephalitis vaccine of the mouse brain type for human use was licensed in Japan. However, there was strong criticism of mouse brain vaccine, which has continued for many years. Therefore, in 1965, the Nippon Institute of Biological Products and the Biken Foundation implemented more advanced purification procedures, such as alcohol precipitation and ultracentrifugation. 

Aral, Y. Kim, S.Y. Kinemuchi, H. Tadano, T. Satoh, S. and Satoh, N. Inhibition of brain type A monoamine oxidase and 5-hydroxytryptamine uptake by two amphetamine metabolites, p-hydroxyamphetamine and p-hydroxynorephedrine. JNeurochem 55 403-408, 1990. 

FIG. 5. Lamotrigine binding to the local anaesthetic receptor site in transmembrane segments IIIS6 and IVS6 of the rat brain type IIA Na channel. Side view of the proposed location of the lamotrigine binding site within the pore. 

Kellenberger S, West JW, Scheuer T, CatteraU WA 1997 Molecular analysis of the putative inactivation particle in the inactivation gate of brain type IIA Na channels. J Gen Physiol 109 589-605... 

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