Brain, phosphorus metabolism

Phosphorus MRS studies of depressed subjects strongly indicate that this disorder arises from altered brain energy metabolism 944 Hydrogen MRS has revealed unique and consistent metabolic characteristics in the brains of patients with probable AD 944 Hydrogen and phosphorus MRS have proven to be useful tools in the characterization of several epilepsies 944... 

T. Kato, S. Takahashi, T. Shioiri and T. Inubushi, Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy. /. Affect. Disord., 1992, 26,223-230. 

More recently Nelson and Bamum (1960) have demonstrated an effect on brain phosphatidylcholine metabolism, occurring a very short time after the injection of 2.5 mg/kg body weight of DFP. After 3 hours the level of energy-rich phosphorus compounds was unaffected, but the transfer of from the acid-soluble pool to the phospholipids was significantly... 

Pettegrew, J. W., Keshavan, M. S., Panchalingam, K. et al. Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy. Arch. Gen. Psychiat. 48 563-568,1991. 

No quantitative information on absorption, distribution, metabolism, and excretion of white phosphorus following inhalation, oral, dermal, and dermal bum exposure was located. Studies in which 32P-labeled white phosphorus was orally administered to animals demonstrated that the label was widely distributed throughout the body, with some of the highest concentrations in the liver, kidney, blood, spleen, and brain (Cameron and Patrick 1966 Lee etal. 1975). 

Phosphorus occurs in nature mainly as the minerals apatite, Ca5(P04)3F, hydroxy-apatite, Ca,r,(P04)3(0H), and tricalcium phosphate (phosphate rock, ranging in composition from Ca3(P04)o to hydroxyapatite). Kydroxy-apatite is the main mineral constituent of the bones and teeth of animals, and complex organic compounds of phosphorus are essential constituents of nerve and brain tissue and of many proteins, and are involved significantly in the metabolic reactions of living organisms. 

Brooks KJ, Kauppinen RA, Williams SR, et al. 1989. Ammonia causes a drop in intracellular pH in metabolizing cortical brain slices A phosphorus-31 and proton NMR study. Neuroscience 33(1) 185-192. 

Chaboaff, E., and A. S. Kbston The metabolism of aminoethylphosphoric acid, followed by means of the radioactive phosphorus isotope. J. biol. Chem. 134, 515—22 (1940). Chojnacki, T., T. Korzybski, and G. B. Ansell The methylation of natural and unnatural analogues of pjabelled phosphatidylethanolamine by brain and liver tissue. Biochem. J. 90, 18P—19P (1964). 

The embryonic morphogenesis of alkaline and acid phosphatases in fish (Tatarskaya et al., 1958), in the rat kidney (Pinkstaff et al., 1962), the rat lung (Zawistowska et al., 1963), the mouse brain (Lierse, 1963), the chick brain (Lee et al., 1961), in insects (Chaudhary and Lemonde, 1964), etc and of several other enzymes of phosphorus and nucleotide metabolism (Donath, 1962 Baker and... 

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