Aminoethylphosphoric acid

Busch and Pennington have prepared the [Co OP(02H)CH(Me)NH3 (NH3)5] + ion containing O-bound 1-aminoethylphosphoric acid, but it remains to be isolated and fully characterized. The terminal amine group has a of 3.2 and the deprotonated complex acts as a bridge for intersphere electron transfer with Cr qj. A scries of diphosphonate chelates of type (164) have been prepared (Table 47) and fully characterized. Crystal structures on the parent (R, = H) bis(ethylenedi-... 

Chaboaff, E., and A. S. Kbston The metabolism of aminoethylphosphoric acid, followed by means of the radioactive phosphorus isotope. J. biol. Chem. 134, 515—22 (1940). Chojnacki, T., T. Korzybski, and G. B. Ansell The methylation of natural and unnatural analogues of pjabelled phosphatidylethanolamine by brain and liver tissue. Biochem. J. 90, 18P—19P (1964). 

The path of conversion of inorganic phosphate to phosphatide is not known. Glycerophosphate, diglycerides, neutral fat, choline phosphate, phosphoproteins, or other compounds may be involved as intermediates. That aminoethylphosphoric acid can be excluded from this group of substances follows from the work of Chargaff and Keston (38). Experiments in which 80 mg. of labeled disodium aminoethyl phosphate was administered to adult rats by subcutaneous injection showed that the body was unable to utilize aminoethylphosphoric acid as such for the synthesis of cephalin. Of the administered as aminoethylphosphoric acid, 28% was found to be excreted through the kidneys in the course of eight hours in these experiments. 

Enzymic hydrolysis of aminoethylphosphoric acid in the tissues is presumably followed by utilization of the inorganic phosphate for synthesis of lecithin and of demethylation of lecithin to form cephalin. The aminoethylphosphoric acid normally occurring in the body tissue may be a product of catabolism of cephalin. 

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