Brain injury neurogenesis

After cerebral stroke and traumatic brain injury, there is a striking amount of neurological recovery in the following months and years, despite often-permanent structural damage. The increase in neurogenesis would also be a factor contributing to the plasticity of CNS, particularly in relation to the recovery in the CNS after injury. 

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Models of Brain Injury Showing Induction of Neurogenesis... 

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Some of the markers that could be used for analyzing early steps of adult neurogenesis have also some limitations. For example, GFAP not only is expressed by neuronal precursors but also by mature astrocytes, and nestin can be reexpressed by reactive glial cell in case of neurotoxicity or brain injury. Thus, MSI-1 or Sox-2 may represent more suitable markers for precursors. 

With the confirmation that neurogenesis occurs in the adult brain, and the recent isolation and characterization in vitro of neural progenitor and stem cells from the adult CNS, new avenues for the treatment of neurological diseases and injuries are being considered. Cell therapeutic interventions may involve both in vivo stimulation and transplantation of neural progenitor and stem cells. 

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