Lactotransferrin bovine

Table 4. Amino acid composition of bovine lactotransferrin and bovine serum...

The relationship of lactotransferrin to serum transferrins is more obscure. Derechin and Johnson (33) found that bovine lactotransferrin had two distinct immunologic components, one of which reacted similarly to blood serum transferrin and one which did not react with blood serum transferrin. Komatsu et al. (83) found immunologic cross reactivity between human serum transferrin and human lactotransferrin, but the cross reactivity was not strong. 

Blanc, B E. Bujard, and J. Mauron The amino acid composition of human and bovine lactotransferrins. Experientia 19, 299 (1963). 

Bovine lactotransferrin possesses five potential glycosylation sites, but the presence of only four glycans has been demonstrated and Asn-281 has not been glycosy-... 

Caprine lactotransferrin has, like bovine lactotransferrin, five potential glycosylation sites (Fig. 4), but the location of glycans has not yet been defined. 

Lactotransferrins also possess a bactericidal effect observed in 1977 by Arnold et al. [176] according to Tomita et al. [177,178] this is due to the liberation of short peptides like lactoferricin B (fragment 17-41 of bovine lactotransferrin) by partial proteolysis. Lactoferricin B derived from the peptidic segment binding to lactotransferrin receptors. The industrial interest in lactoferricin is evident. 

As mentioned above (see section 2.2.1), the three-dimensional structure of the peptide chains of rabbit serotransferrin, of human and bovine lactotransferrins and of ovotrans-... 

Fig. 9.—Structure of Glycans105 of Bovine-milk Lactotransferrin ( Red Protein ).

Lactoferrin was first identified as a red protein fraction in human milk (1). The milk protein has been called by various names of red milk protein, ekkrino-siderophilin, and lactotransferrin which is in turn very similar in many respects to transferrin, the ironbinding protein of serum. The concentration of lactoferrin in human milk is unusally rich with a range of 7 mg/ml in colostrum to approximately 1 mg/ml in mature milk (2). However, the bovine colostrum contains lactoferrin at concentrations of 5 mg/ml, which drops very rapidly with stage of lactation to where mature bovine milk contains 20-200 pg/ml of lactroferrin (3). Lactoferrin is also found in various other exocrine secretions of the body such as vaginal, nasal, bronchial and intestinal (4 6). 

Lactoferrin, lactotransferrin. Important component of the human milk bacteriostatic system also found in human and bovine tear proteins. Isoln from human whey by a single chromatographic step L. Blackberg, O. Hernell, FEES... 

Human colostrum and milk contain 6-8 mg ml and 2-4 mg ml lactotransferrin, respectively, representing about 20% of the total protein in the latter bovine colostrum and milk contain about 1 and 0.02-0.35 mg ml respectively. The concentration of lactotransferrin in human milk decreases slightly during lactation but appears to increase slightly in bovine milk and very markedly during the dry period. 

Lactotransferrins have been isolated from the milks of several species, including human and bovine, and some have been well characterized, including determination of their amino acid sequence. Some of the isolation procedures have industrial-scale potential the preparations obtained from such procedures usually contain both Lf and LPO. 

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