Segments, peptide

Peptide segments obtained by a second type of cleavage... 

Implicit in the presumption of folding pathways is the existence of intermediate, partially folded conformational states. The notion of intermediate states on the pathway to a tertiary structure raises the possibility that segments of a protein might independently adopt local and well-defined secondary structures (a-helices and /3-sheets). The tendency of a peptide segment to prefer a particular secondary structure depends in turn on its amino acid composition and sequence. 

The central rod domain of a keratin protein is approximately 312 residues in length. What is the length (in A) of the keratin rod domain If this same peptide segment were a true u-helix, how long would it be If the same segment were a /3-sheet, what would its length be ... 

FIGURE 17.26 The o i-subuiiit of the t-tubule Ca" chainiel/DHP receptor contains six peptide segments that may associate to form the Ca" channel. This Ca" channel polypeptide is homologous with the voltage-sensitive Na channel of neuronal tissue. 

Brasseur R, Cornet B, Burny A, Vandenbranden M, Ruysschaert JM (1988) Mode of insertion into a lipid membrane of the N-terminal HIV gp41 peptide segment. AIDS Res Hum Retroviruses 4 83-90... 

Albericio F, Barany G. Hypersensitive acid-labile (HAL) tris(alkoxy)benzyl ester anchoring for solid-phase synthesis of protected peptide segments. Tetrahedron Lett 1991 32 1015-1018. 

Synthetic haptens mimicking some critical epitopic structures on larger macromolecules are often conjugated to carriers to create an immune response to the larger parent molecule. For instance, short peptide segments can be synthesized from the known sequence of a viral coat protein and coupled to a carrier to induce immunogenicity toward the native virus. This type of synthetic approach to immunogen production has become the basis of much of the current research into the creation of vaccines. 

CSA [46]. The local alignment of a peptide segment can thus be described by a C-CF3 vector that protrudes in a well-defined way from the a carbon on the backbone (see Sect. 2.2 on 19F-labelled amino acids). 

Vassilev, P., Scheuer, T. and Catterall, W. A. Identification of an intracellular peptide segment involved in sodium channel inactivation. Science 241,1658-1661,1988. 

S Pass, B Amit, A Parchomik. Racemization-free photochemical coupling of peptide segments. (Fmoc-amino-acid chlorides) J Am Chem Soc 103, 7674, 1981. 

LA Carpino, BJ Cohen, KE Stephens, SY Sadat-Aalaee, J-H Tien, DC Lakgridge. (9-Fluorenylmethyl)oxycarbonyl (Fmoc) amino acid chlorides. Synthesis, characterization, and application to the rapid synthesis of short peptide segments. J Org Chem 51, 3732, 1986... 

LA Carpino, D Ionescu, A El-Faham. Peptide segment coupling in the presence of highly hindered tertiary amines. J Org Chem 61, 2460, 1996. 

Nakagawa, ET Kaiser. Synthesis of protected peptide segments and their assembly on a polymer-bound oxime application to the synthesis of a peptide model for plasma apolipoprotein A-I. J Org Chem 48, 678, 1983. 

P Wang, R Layfield, RJ Mayer, R Ramage. Transfer active ester condensation a novel technique for peptide segment coupling. Tetrahedron Lett 39, 8711, 1998. 

J Blake. Peptide segment coupling in aqueous medium silver ion activation of the thiolcarboxylic group. Int J Pept Prot Res 17, 273, 1981. 

M Gain, P Lloyd-Williams, F Albericio, E Giralt. Convergent solid-phase peptide synthesis. 12. Chromatographic techniques for the purification of protected peptide segments. Int J Pept Prot Res 46, 119, 1995. 

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