Bovine colostrum

In agreement with abundant mRNA in mammary gland, high levels of apelin are present in bovine colostrum oral intake of apelin might modulate immune responses in neonates [4]. 

Korhonen, H. (1977). Antimicrobial factors in bovine colostrum. /. Sci. Agric. Soc. Finland 49, 434r-447. 

N.m.r.-spectroscopic studies have furthennore shown that sialyl-transferase from bovine colostrum preferentially incorporates sialyl residues into a-(2— 6) linkages of glycopeptides from oq-acid glycoprotein.162... 

Bezkorovainy, A. and Grohlich, D. 1969. Separation of the bovine colostrum M-l glycoproteins into two components. Biochem. J. 115, 817-822. 

Froese, A. 1971. Isolation of dinitrophenyl-specific antibodies from bovine colostrum. Can. J. Biochem. 49, 522-528. 

Kumar, S. and Mikalajcik, E. M. 1973. Selected physicochemical characteristics of bovine colostrum immunoglobulin. J, Dairy Sci. 56, 255-258. 

Mach, J.-P., Pahud, J. J. and Isliker, H. 1969. IgA with secretory piece in bovine colostrum and saliva. Nature 223, 952-954. 

Table 4.4. Content of Glycerol Ethers In Neutral Lipids and Phospholipids Isolated from Bovine Colostrum (Means from Four Swedish Red and White Cows from Days 1 to 5) and Milk (Mean for Four Swedish Red and White Cows from 2nd Wk to 7th Mo)a Week 2 to Month 7.

Colostral Lipase. Driessen (1976) identified a lipase in bovine colostrum which is stable at pH 4.6, is bound to casein micelles, but is situated in the milk serum. Binding to heparin-Sepharose was weak, and... 

Driessen, F. M. 1976. A comparative study of the lipase in bovine colostrum and in bovine milk. Neth. Milk Dairy J. 30, 186-196. 

Powell, J. T., Jalfors, U. and Brew, K. 1977. Enzymic characteristics of fat globule membranes from bovine colostrum and bovine milk. J. Cell Biol. 72, 617-627. 

N-Acetyl-/ -D-glucosaminide-(l - 4)-/J-D-galactosyltransferase, from bovine colostrum, first substituted trisaccharide 90 (which is the partial structure of the branching point in blood-group I, antigenic structures) at the... 

The basis for the multiplicity of the sialyltransferase activities remains to be elucidated. We plan to purify these enzyme species to homogeneity, using isoelectric focusing columns of smaller pH ranges in conjunction with affinity chromatography which has been successfully used to purify the soluble sialyl-transferases from bovine colostrum (57). Possibility exists that the heterogeneity of sialyltransferase activities as observed is due to differences in polypeptide sequences, carbohydrate content, or non-covalent interactions with other membrane components, and these possibilities can be clarified only with highly purified enzyme preparations. 

Merin, U., Bernstein, S.D., Bloch-Damti, N., Yagil, R., van Creveld, C., and Lindner, P. 2001. A comparative study of milk proteins in camel (Camelus dromedarius) and bovine colostrum. Livestock Product Sci 67 297-301. 

CONCENTRATION AND SUGGESTED BIOLOGICAL FUNCTIONS OF MAJOR PROTEINS OF BOVINE COLOSTRUM AND MILK... 

Nutritional significance. As one of the major whey proteins in human milk and also relatively abundant in bovine colostrum, LF is of interest as a dietary source of amino acids as well as for the bioavailability of iron. LF has an... 

Casswall, T.H., Sarker, S.A., Albert, M.J., Fuchs, G.J., Bergstrom, M., Bjorck, L., and Hammarstrom, L. 1998. Treatment of Helicobacter pylori infection in infants in rural Bangladesh with oral immunoglobulins from hyperimmune bovine colostrum. Aliment. Pharmacol. Ther. 12,563-568. 

Davidson, G.P., Daniels, E., Nunan, H., Moore, A.G., Whyte, P.B.D., Franklin, K., McCloud, P.I., and Moore, D.J. 1989. Passive immunisation of children with bovine colostrum containing antibodies to human rotavirus. Lancet 2, 709 -712. 

Dominguez, E., Perez, M.D., and Calvo, M. 1997. Effect of heat treatment on the antigen-binding activity of anti-peroxidase immunoglobulins in bovine colostrum. J. Dairy Sci. 80, 3182-3187. 

Mero, A., Miikkulainen, H., Riski, J., Pakkanen, R., Aalto, J., and Takala, T. 1997. Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, saliva IgA during training. J. Appl. Physiol. 83, 1144-1151. 

Oona, M., Rago, T., Maaroos, H., Mickelsaar, M., Loivukene, K., Salminen, S., and Korhonen, H. 1997. Helicobacter pylori in children with abdominal complaints has immune bovine colostrum some influence on gastritis Alpe Adria Microbiol. J. 6, 49-57. 

Pakkanen, R. and Aalto, J. 1997. Growth factors and antimicrobial factors of bovine colostrum. Int. Dairy J. 7, 285-297. 

Perryman, L.E., Kapil, S.J., Jones, M.L., and Hunt, E.L. 1999. Protection of calves against cryptosporidiosis with immune bovine colostrum induced by a Cryptosporidium parvum recombinant protein. Vaccine 17, 2142-2149. 

Roos, N., Mahe, S., Benamouzig, R., Sick, H., Rautureau, J., and Tome, D. 1995. 15-N-labeled immunoglobulins from bovine colostrum are partially resistant to digestion in human intestine. J.Nutr. 125, 1238-1244. 

At parturition, the proportions of C12 to Ci6 fatty acids are relatively high in bovine colostrum. Proportions of short-chain fatty acids and stearic and oleic acids increase rapidly as the mobilization of adipose tissue commences, becoming relatively stable by one week after parturition (Laakso et al., 1996). 

As detailed in Section III, initial raw materials for the production of antibodies are very different. Animal sera, transgenic milk, bovine colostrum, cell culture (hybridomas or other recombinant cells), ascites fluid, and egg yolk are the best known. Each raw material represents a potential carrier for adventitious agents. All of them can contain viruses. More specifically, animal sera used as source of antibodies, or as a cell culture medium supplement, can additionally carry mycoplasma and pyrogens depending on the method of collection. 

Bovine colostrum as well as milk whey contain essentially bacteria and pyrogenic substances and may contain viruses. Humanized or specifically reconstructed antibodies from transgenic animals can contain traces of endogenous antibodies from the host animal that are very difficult to separate from the newly expressed molecules. 

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