Bone marrow cough

Bone marrow depression, anemia, blood dyscrasias, nausea, vomiting, tachycardia, itching, rash, hives, tenderness and swelling of the neck, sore throat, and cough... 

Reactions after administration of 131I include sore diroat, swelling in the neck, nausea, vomiting, cough, and pain on swallowing. Otiier reactions include bone marrow depression, anemia, leukopenia, thrombocytopenia, and tachycardia... 

Symptoms Erythema, Blisters, Irritation of the Eyes, Cough, Dyspnea, Asymtomatic Latent Period (hours). Also, mild upper respiratory signs to marked airway damage, GI effects and bone marrow stem cell suppression possible. Mustard is a blister agent that affects the eyes, lungs, and skin. A person exposed to mustard will feel very little pain and... 

SYSTEMIC EFFECTS Occurs primarily through inhalation and ingestion. The T vapor or aerosol is less toxic to the skin or eyes than the liquid form. When inhaled, the upper respiratory tract (nose, throat, tracheae) is inflamed after a few hours latency period, accompanied by sneezing, coughing and bronchitis, loss of appetite, diarrhea, fever, and apathy. Exposure to nearly lethal doses of T can produce injury to bone marrow, lymph nodes, and spleen as indicated by a drop in white blood cell (WBC) count and, therefore, results in increased susceptibility to local and systemic infections. Ingestion of T will produce severe stomach pains, vomiting, and bloody stools after a 15-20 minute latency period. 

Many patients experience a dry cough, especially when beginning treatment. This may be due to the accumulation of bradykinin in the bronchial mucosa. Less frequent are angioedema, xanthelasma and bone marrow suppression. 

Recombinant human IL-11 (oprelvekin) is a polypeptide of 177 amino acids. It differs from natural IL-11 due to lack of glycosylation and the amino-terminal proline residue. Oprelvekin is administered by subcutaneous injection, usually 6-24 h after chemotherapy, at a dose of 25-50 p,g/kg per day. The drug has a half-life of about 7h. It is used to stimulate bone marrow to induce platelet production in nonmyeloid malignancies in patients undergoing chemotherapy. The common side effects of oprelvekin include fluid retention, tachycardia, edema, nausea, vomiting, diarrhea, shortness of breath and mouth sores. Other side effects include rash at the injection site, blurred vision, paresthesias, headache, fever, cough and bone pain. Rarely, CLS may occur. 

There is no specific therapy for mustard injuries of the respiratory tract. Severe coughing may be eased with codeine linctus. Antibiotic cover is recommended, the antibiotic chosen not being one liable to induce further bone marrow depression. Acetylcysteine was used in some patients from the Iran-Iraq War as a mucolytic. Evidence of its efficacy is scanty. 

SY Irrit eyes, skin, nose, throat head cough, dysp nau, vomit olfactory, taste changes chemical pneu (aspir liquid) in animals liver, kidney, urogenital inj bone marrow effects... 

Bacterial superinfection of pox lesions was relatively uncommon except in the absence of proper hygiene and medical care. Arthritis and osteomyelitis developed late in the course of disease in about 1% to 2% of patients, more frequently occurred in children, and was often manifested as bilateral joint involvement, particularly of the elbows.70 Viral inclusion bodies could be demonstrated in the joint effusion and bone marrow of the involved extremity. This complication reflected infection and inflammation of a joint followed by spread to contiguous bone metaphyses, and sometimes resulted in permanent joint deformity.71 Cough and bronchitis were occasionally reported as prominent manifestations of smallpox, with attendant implications for spread of contagion however, pneumonia was unusual.72 Pulmonary edema occurred frequently in hemorrhagic- and flat-type smallpox. Orchitis was noted in approximately 0.1% of patients. Encepha-... 

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