Body weight genetic factors

Elevated cholesterol levels in transplant patients are due to a culmination of factors such as age, genetic disposition, renal dysfunction, DM, proteinuria, body weight, and immunosuppressive therapy. Many of the immunosuppressive agents can produce elevations in serum lipid levels. 

The adjustment of dose and dosing regimen for children and the elderly needs a special consideration because of several differences as compared to an adult individual. The differences may be due to many factors which include changes in pharmacokinetic parameters, age, body weight, surface area, and genetic predisposition. The present chapter provides some basic explanation about their differences and the dosage calculations because of these differences. 

Type 2, also known previously as non-insulin-dependent diabetes mellitus (NIDDM), accounts for 90 to 95 percent of persons with diabetes mellitus.19 This form of diabetes usually occurs in adults, especially in older individuals.35,102 Type 2 diabetes, however, can also occur in young people, and there is concern that the incidence of this disease is increasing dramatically in children and adolescents.9,83 Although the specific factors responsible for this disease are unknown, a genetic predisposition combined with poor diet, obesity, and lack of exercise all seem to contribute to the onset of type 2 diabetes.50,81,83 Increased body weight is common in patients with type 2 diabetes. 

Intrinsic ethnic factors that may include age, gender, height, weight, lean body mass, genetic polymorphism, body composition, other illness, and organ dysfunction (e.g., renal or hepatic impairment). 

Brock A and Brock V (1993). Factors affecting interindividual variation in human plasma cholinesterase activity body weight, height, sex, genetic polymorphisms and age. Arch Environ Contam Toxicol, 24, 93-99. 

Maes HH, Neale MC, Eaves LJ. Genetic and environmental factors in relative body weight and human adiposity. Behav. Genet. 1997 27 325-351. 

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