Desirable body weight

We were surprised to find that no method existed that was sensitive enough to detect TCDD in animal tissues even after administration in some species of lethal doses. An example is the guinea pig, the most susceptible species of the few that have been tested, and therefore a good choice for establishing desirable limits of detection. The lethal single oral dose (LD50) in males of this species is 0.6 /xg/kg body weight... 

Total calories Adjust caloric intake to maintain desirable body weight and prevent weight gain... 

The objectives of dietary therapy are to progressively decrease the intake of total fat, saturated fat, and cholesterol and to achieve a desirable body weight (Table 9-4). 

Approximately 15% of total calories To achieve and maintain desirable body weight... 

High serum triglycerides (see Table 9-1) should be treated by achieving desirable body weight, consumption of a low saturated fat and cholesterol diet, regular exercise, smoking cessation, and restriction of alcohol (in selected patients). 

Loading dose (mEq) = (Vd HC03 x body weight) x (desired [HC03 ] - current [HC03 ])... 

If the test substance contains only 75% active ingredient and the investigator chooses a constant dose volume of 10 ml kg 1 body weight across all dose levels, it will be more convenient to prepare a stock solution such that when 10 ml kg 1 of this stock solution is given to the animal, the dose will be the desired one (say 500 mg kg 1 of active ingredient). The concentration of this stock solution would be (500mg/10ml)/0.75 = 66.7mg of the test substance per milliliter of diluent. 

L/kg) X body weight (kg) x desired increase in serum HCO3- (mEq/L) = bicarbonate dose (mEq)... 

Infants and children Levothyroxine therapy usually is initiated at full replacement doses, with the recommended dose per body weight decreasing with age (see table). However, in children with chronic or severe hypothyroidism, an initial 25 mcg/day dose of levothyroxine is recommended with increments of 25 meg every 2 to 4 weeks until the desired effect is achieved. 

Gabapentin [Neurontin] Adult initially, 300 mg TID. Can be gradually increased up to 3600 mg/d based on desired response. Children (3-12 years of age] Initially, 10-15 mg/kg body weight in 3 divided dosages increase over 3 days until desired effect or a maximum of 50 mg/kg/d. Developed originally as an anticonvulsant may also be helpful as an adjunct to other drugs in treating spasticity associated with spinal cord injury and multiple sclerosis. 

In the case of adult subjects, the most suitable expression seems unquestionably to be one indicating the amounts (in mg) per 24-hr collection, both for free and for combined amino acids. When relative amounts are of interest, it is of course preferable to compute the amounts on a molar basis (S24). For the sake of possible comparison with other data than one s own, it is always highly desirable to indicate at the same time, total nitrogen output, 24-hr urine volume, body weight, and, if possible, body height. 

Some clinical chemists have found it suitable to adopt another unit basis of comparison, namely, a conventionally adopted amount of creatinine excretion. We feel that it is not advisable to encourage this procedure as one to be advocated as a standard for purposes of computation, particularly if it eventually becomes confirmed that creatinine excretion may not be as constant as it has been claimed to be, according to a recent publication (V7). In case the creatinine basis of reference is adopted, however, by certain workers, it is certainly highly desirable to indicate at the same time the urine volume output in 24 hours, the nitrogen output, as well as the creatinine output, and finally also the body weight. 

Hunger varies inversely with body weight if you lose weight the desire to eat more food becomes more powerful. 

Caution must be exercised when using cycloplegic agents in infants, because they are more susceptible to systemic complications due to their immature metabolism and excretion systems and their low body weight. The clinician should use the lowest concentration of drug that yields the desired cycfoplegia. 

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