Blood Glucose Lowering Activity in Conscious Rabbits

Blood Glucose Lowering Activity in Conscious Rabbits [Pg.180]

Groups of 4-5 mixed breed rabbits of either sex weighing 3.0-4.5 kg are used. For insulin evaluation, food is withheld overnight. For evaluation of sulfonylureas and other blood glucose lowering agents the animals [Pg.180]

Oral blood glucose lowering substances are applied by gavage in 1 ml/kg of 0.4% starch suspension or intravenously in solution. Several doses are given to different groups. One control group receives the vehicle only. By puncture of the ear veins, blood is withdrawn immediately before and 1,2,3,4, 5,24,48, and 72 hours after treatment. For time-response curves values are also measured after 8,12,16, and 20 hours. Blood glucose is determined in 10 pi blood samples. [Pg.180]

Bander A, Pfaff W, Schmidt FH, Stork H, Schroder HG (1969) Zur Pharmakologie von HB 419, einem neuen, stark wirk-samen oralen Antidiabeticum. Arzneim Forsch/Drug Res 19 1363-1372 [Pg.180]

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