Bladder cancer deficiency

TGFa-PE4o (TP40) Tissue growth factor-alpha (TGF-a) Binds to TGF receptors overexpressed on solid tumors PE40 is a binding-deficient variant of PE Cytotoxicity Evaluated in phase I testing for bladder cancer [106]... 

Tissue-specific NAT expression can ajfect toxicity of environmental pollutants. NATl is ubiquitously expressed in human tissues, whereas NATl is found in liver and the GI tract. Both enzymes have a capacity to form N-hydroxy-acetylated metabolites from bicyclic aromatic hydrocarbons, a reaction that leads to the nonenzymatic release of the acetyl group and the generation of highly reactive nitrenium ions. Thus, N-hydroxy acetylation is thought to activate certain environmental toxicants. In contrast, direct N-acetylation of the environmentally generated bicyclic aromatic amines is stable and leads to detoxification. NATl fast acetylators efficiently metabolize and detoxify bicyclic aromatic amine through liver-dependent acetylation. Slow acetylators (NATl deficient) accumulate bicyclic aromatic amines, which are metabolized by CYPs to N-OH metabolites that are eliminated in the urine. In bladder epithelium, NATl efficiently catalyzes the N-hydroxy acetylation of bicyclic aromatic amines, a process that leads to deacetylation and the formation of the mutagenic nitrenium ion. Slow acetylators due to NATl deficiency are predisposed to bladder cancer if exposed to environmental bicyclic aromatic amines. 

Menstrual losses of blood average 28 milligrams monthly. One in four college-age women are iron deficient, possibly due to ignoring the need for increased iron intake prior to and during menstruation. Diseases that cause iron deficiency are colon cancer, hiatal hernia, ulcers, hemorrhoids, bladder tumor, and diverticulosis. Soft drinks high in phosphates cause iron to be excreted in the urine. Lack of copper or manganese in the diet reduces iron assimilation, as does a deficiency of vitamin C. Oxalic acid foods, such as chard and rhubarb, can block iron intake. 

Considering individually antioxidant nutrients included in MeD, recent studies reported that P-carotene deficiency is associated with increasing risk for lung, bladder and lar5mgeal cancer. On the contrary, vitamin C as a nutrient included in fruit and vegetables seemed to be protective against esophageal and stomach cancer. Vitamin E, included in foods such as olive oil and nuts has also proven to exert beneficial effects in cancers of the... 

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