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Bisabolol

Diastereoselective biohydrolysis of (4S,8/ S)-limonene oxide using whole cells of the strain Aspergillus niger LCP 521 as a biocatalyst, leading to the synthesis of a-bisabolols. [Pg.211]


OC-Bisabolol. a-Bisabolol (99) occurs in camomile flowers and has been shown to be the main antiphlogistic and spasmolytic component of the European medicinal plant. The use of bisabolol is recommended mainly for its pharmacodynamic properties in cosmetic preparations for skin protection. [Pg.428]

In perfumery bisabolol functions as a fixative. The racemic form is manufactured by the acid-catalyzed cyclization of nerohdol (193). [Pg.428]

The detection limits per chromatogram zone are 250 ng for bisabolol and 40 ng for bisabolol dioxide [10]. [Pg.128]

Bisabolol oxide (h/ f 40-45) appeared as pink and bisabolol (tiRf 65-70) as mauve-colored chromatogram zones on a pale yellow background. The detection limits per chromatogram zone were 40 ng for bisabolol oxide and 250 ng for bisabolol. [Pg.128]

Fig 1 Chromatogram of a chamomile flower extract and of chamomile oil components (A) and reflectance scans (B) of reference tracks with 3.75 pg bisabolol oxide (1) and 9.5 pg bisabolol (2) and a chromatogram track with chamomile flower extract (3). [Pg.129]

Vanillosmopsis erythropappa Schultz-Bip. is a component of the Atlantic coastal forest in Brazil, where it is exploited as a source of an essential oil used in the pharmaceutical industry. A survey of specimens from four locations showed markedly different compositions of their essential oil fraction (Lopes et al., 1991). The compounds identified were bisabolol [160], costunolide [161], eremanthine [162], and five related compounds, six compounds based upon the cyclocostunolide skeleton [163], and the two esters 15-deoxygoyazenolide [164] and lychnopholide [165]... [Pg.68]

The dried capitula of Matricaria chamomilla L. (Asteraceae), or German chamomile, have been used as anti-inflammatory and antispasmodic remedies since very early times on account of its contents in bisabolol oxides the activity of which has been experimentally substantiated. The plant is listed in several European pharmacopeias, and is used in the form of tinctures, extracts, lotions, ointments, shampoos, and sunscreen products. [Pg.14]

Bis(4-isocyanatophenyl)methane (MDI), with alkyd resins, 2 164 a-Bisabolol, 24 548... [Pg.105]

Keywords Biodiversity, /-/-a-bisabolol, /-/-a-bisabololoxide A and B, chamazu-lene, chamomile, chemo types, essential oil, sesquiterpenes... [Pg.87]

About 120 chemical constituents have been identified in chamomile as secondary metabolites, including 28 terpenoids, 36 flavonoids and 52 additional compounds [4]. A substantial part of drag effects are determined by the essential oil content. Oil is collected from flower heads, either by steam distillation or solvent extraction, for yields of 0.24-1.90% of fresh or dry plant tissue. Among the essential oil constituents the most active are /-/-a-bisabolol and chamazulene. /-/-a-bisabolol has demonstrated anti-inflammatory, antispasmodic, antimicrobial, antiulcer, sedative and CNS activity. Chamazulene is also anti-inflammatory. Topical applications of chamomile preparation have shown benefit in the treatment of eczema, dermatitis and ulceration [5]. [Pg.88]

Compound identification. Determination of major components of essential oil was realized on the basis of use of standard compounds (/-/-a-bisabolol, chamazu-lene, cis-/trans-en-in-dicycloether and /-/-a-bisabololoxide A and B). Qualitative identification of selected components was carried out by the comparison the retention times of all detected components with retention time of standard compounds. [Pg.89]

The highest contents of /-/-a-bisabololoxide A (39.9 7.5%) and /-/-a-bisabo-loloxide B (9.75 4.20%) are typical for chamomile plants, which flower anthodia were collected in various places in the East-Slovakian Lowland. In regard to following sesquiterpenes, the chamomile anthodia contain /-/-a-bisabolol (5.09 1.55%) and chamazrrlene (7.65 3.90%). [Pg.89]

Flowers have a highest /-/-a-bisabololoxide A content, about 41% (Table 7.2). The pharmaceutically effective components (/-/-a-bisabolol and chamazulene) have a lower representation. [Pg.90]

One from very important exporter in the world of the chamomile flowers is Egypt. The possibility to visit some chamomile production areas in this African country occured several times in 1997 and 1998. Chamomile flowers from different Egyptian areas have a highest /-/-a-bisabololoxide content, from 40.1% to 68.2% (Table 7.4). The pharmaceutically effective components (/-/-a-bisabolol and... [Pg.91]

Table 7.5 The /-/-a- bisabolol chamomile from two European Isles... Table 7.5 The /-/-a- bisabolol chamomile from two European Isles...
Chamomile contains the terpenoids (-)-alpha-bisabolol, (-)-alpha-bisabololoxides A and B, and a gauianolide lactone called matricin. Also contained are the flavonoids apigenin and apigenin-7-glucoside (see figure 6.6) (Tyler 1994 Robbers et al. 1996). Apigenin was found... [Pg.240]

The bisabolanes, of which eight have been reported in these studies, also deserve special mention. Again, Z,E-farnesyl pyrophosphate is the putative progenitor. One study (13) reported 3-bisabolol (199) to be about 34% of the volatile alcohol fraction, making it about 5% of the total essential oil. a-Bisabolene (193) is representative of the hydrocarbons of this group. [Pg.292]

Another illustration of the use of such a biocatalytic approach was the synthesis of either enantiomer of a-bisabolol, one of these stereoisomers (out of four) which is of industrial value for the cosmetic industry. This approach was based on the diastereoselective hydrolysis of a mixture of oxirane-diastereoiso-mers obtained from (R)- or (S)-limonene [68]. Thus,starting from (S)-hmonene, the biohydrolysis of the mixture of (4S,81 S)-epoxides led to unreacted (4S,8S)-epoxide and (4S,8i )-diol. The former showed a diastereomeric purity (> 95%) and was chemically transformed into (4S,8S)-a-bisabolol. The formed diol... [Pg.161]

Scheme 15. Chemoenzymatic synthesis of a-bisabolol using fungal epoxide hydrolase... Scheme 15. Chemoenzymatic synthesis of a-bisabolol using fungal epoxide hydrolase...

See other pages where Bisabolol is mentioned: [Pg.569]    [Pg.127]    [Pg.862]    [Pg.43]    [Pg.36]    [Pg.90]    [Pg.91]    [Pg.91]    [Pg.91]    [Pg.92]    [Pg.92]    [Pg.92]    [Pg.92]    [Pg.92]    [Pg.92]    [Pg.92]    [Pg.92]    [Pg.93]    [Pg.287]    [Pg.287]    [Pg.162]    [Pg.162]    [Pg.162]    [Pg.300]    [Pg.346]   
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A-Bisabolol oxides

A-bisabolol

Alpha-Bisabolol aqueous mouthwash solution

Alpha-Bisabolol buccal or topical solution

Alpha-Bisabolol mouthwash solution

Alpha-bisabolol

Bisabolol oxide

Bisabolol oxide derivatives

Epoxide hydrolases bisabolol

Matricaria bisabolol

P-Bisabolol

Tretinoin and alpha bisabolol gel

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