Matricaria bisabolol

The dried capitula of Matricaria chamomilla L. (Asteraceae), or German chamomile, have been used as anti-inflammatory and antispasmodic remedies since very early times on account of its contents in bisabolol oxides the activity of which has been experimentally substantiated. The plant is listed in several European pharmacopeias, and is used in the form of tinctures, extracts, lotions, ointments, shampoos, and sunscreen products. 

Matricaria Matricaria recutita L. (-)-a-Bisabolol (10-65) and bis-abolol oxides (29-81) types exist... 

Artemisia annua and (—)-o -bisabolol from Matricaria recutita (German chamomile). Addition of IPP to GPP produces 2 , 6 -famesylpyropho-sphate (FPP), the precursor for all sesquiterpenes. Farnesylpyrophosphate can cyclize by various cyclase enzymes in various ways, leading to the production of a variety of sesquiterpenes. Some of these sesquiterpenes are medicinally important hioactive compounds. For example, (—)-o -bisabolol and its derivatives have potent anti-inflammatory and spasmolytic properties, and artemisinin is an antimalarial drug. 

German chamomile Matricaria recutita (Asteraceae) —a-bisabolol and its derivatives... 

Matricaria chamomilla L. (Chamomile) Flowers SD 1.2 bisabolols, ehamazulenes 33... 

CHAMOMILE FLOWERS Matricaria recutita, L., family Asteraceae, contain an essential oil rich in sesquiterpenes such as bisabolol and chamazulene which have excellent antiinflammatory effects. 

CHAMOMILE FLOWERS Matricaria recutita L.), family Asteraceae Chamomile flowers contain chamazulene and bisabolol, whereas white willow, Salicis albae cortex, bark from Salix alba, L., family Salicaceae, contains salicylic acid and its derivatives. These substances have antiseptic and disinfectant effects. 

Monoterpene oxides are relatively reactive, unstable molecules in which an oxygen atom is situated between two carbons. In most cases the oxygen atom substitutes a carbon in the ring of a monoterpenoid—usually an alcohol. An example is bisabolol oxide from chamomile Matricaria chamomilla). However, in the two most significant oxides—1,8-dneole and ascaridole—found in essential oils, the oxygen atoms are attached outside the main hydrocarbon ring. 

FIGURE 3.6 ( ) a Bisabolol content (mg/100 g crude drugj in two chamomile (Matricaria recutita)... 

Matricaria recutita Mabamille DE 1995 Tetraploid High a-bisabolol... 

Acute dermatitis was induced by croton oil, arachidonic acid, phenol, and capsaicin. The dermatitis was treated with a-bisabolol. The EO compound showed good anti in ammatory activity (Leite et al., 2011). (-)-a-Bisabolol is a sesquiterpene alcohol and the main compound of the EO of Matricaria chamomilla L. (Asteraceae). It was evaluated for its anti-in ammatory activity using carrageenan-induced mouse paw edema. a-Bisabolol was able to reduce the paw edema at concentrations of—100 or 200 mg/kg—at pre treatment and so did indomethacin, the positive control. It also had sign cant reduction effect in edema induced by dextran. Rat treatment with sesquiterpene alcohol (100 and 200 mg/kg) showed a sign cant decrease of leukocyte migration on carrageenan-induced peritonitis. The level of TNE-a in the peritoneal uid was de nitely reduced in rats when treated with a-bisabolol (Rocha et al., 2011). 

Definition Blue essential oil obtained by steam distillation of the fresh or dried ower heads or owering tops of Matricaria recutita L. Chamomilla recutita L. Rauschert). There are two types of matricaria oils, which are characterized as rich in bisabolol oxides or rich in (-)-a-bisabolol. 

Content 1. Matricaria oil rich in bisabolol oxides bisabolol oxides 29%-81% chamazulene > 1%. 2. Matricaria oil rich in (-)- a-bisabolol (-)-a-bisabolol 10%-65%, chamazulene > 1%, total of bisabolol oxides and (-)-a-bisabolol > 20%. 

The oxidized bisabolene derivative a-bisabolol with antiphlogistic properties is a main active compound in German chamomile (Matricaria recutita). Depending on the origin of the plants and the chemotype or variety, varying proportions of the oxides (bisabolol oxide A, bisabolol oxide B, or bisabolone oxide A) may be present in the respective oils [30]. a-Bisabolol can also be found in larger... 

Telekin from the roots of Telekia speciosa, helenin from the roots of Inula helenium L., and sesquiterpene alcohol ledol from the aerial parts of Ledum palustre L. show cytotoxicity [41]. Bisabolol, a nontoxic sesquiterpene alcohol, was isolated from Matricaria chamomilla, Carthamus lanatus, and Matricaria recutita and exhibits a cytotoxic apoptosis-inducing effect [42] against human glioblastoma and pancreatic carcinoma cell lines. 

An example of monocyclic sesquiterpenic alcohols is (-l-)-o(-bisabolol (8-24). It occurs in citrus essential oils along with other sesquiterpenic alcohols, and represents the major component of the essential oil of chamomile flowers (Matricaria chamomilla, Asteraceae). a-Bisabolol (0.26%) and other sesquiterpenoids, such as monocyclic sesquiterpenic alcohol (Z)-lanceol (1.7%), bicyclic sesquiterpenic alcohol (Z)-a-essential components of white sandalwood oil (Santalum album, Santa-laceae) used in perfumery, cosmetics and aromatherapy. (Z)-Lanceol is also a component of sage species (Salvia spp., Lamiaceae) essential oil. Sesquiterpenic bicyclic alcohol (-F)-P-nootkatol is the precursor of ketone (-F)-nootkatone, an important component of grapefruit essential oil. Trivial and systematic names of the main sesquiterpenic alcohols are listed in Table 8.7. 

Matricaria oil rich in Bisabolol oxides bisabolol oxides 29-81%, chamazulene >1... 

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