Biphenyls reproductive effects

Polybrominated Biphenyls. A limited amount of information is available regarding reproductive effects in humans after exposure to PBBs. No evidence for PBBs-related effects on sperm counts, motility, or sperm morphology was found in a group of male Michigan workers exposed to PBBs by inhalation or dermal contact (Rosenman et al. 1979). No relationship was found between serum levels of PBBs and the frequency and duration of lactation in women exposed during the Michigan contamination episode (Thomas etal. 2001). 

SAFETY PROFILE Poison by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits ver toxic Br . See also POLYBROMINATED BIPHENYLS. 

CONSENSUS REPORTS lARC Cancer Review Group 3 IMEMDT 48,73,90 Animal Limited Evidence IMEMDT 48,73,90. NTP Carcinogenesis Studies (feed) Some Evidence rat NTPTR NTP-TR-309,86 (feed) Equivocal Evidence mouse NTPTR= NTP-TR-309,86. Polybrominated biphenyl compounds are on the Community Right-To-Know List. Reported in EPA TSCA InventortL SAFETY PROFILE Questionable carcinogen with experimental neoplastigenic data. Experimental reproductive effects. Used as a flame retardant for thermoplastics. When heated to decomposition it emits toxic fumes of Br. See also ETHERS and BROMIDES. 

SAFETY PROFILE Suspected human carcinogen. Moderately toxic by ingestion and skin contact. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl". Used in heat transfer, hydraulic fluids, lubricants, and insecticides. See also POLYCHLORINATED BIPHENYLS. 

Nebeker, A.V., Puglisi, E.A., and Defoe, D.L. (1974). Effect of polychlorinated biphenyl compounds on survival and reproduction of fathead minnow and llagfish. Transactions of the American Fisheries Society 103, 562-568. 

Wren CD, Hunter DB, Leatherland JF, Stokes PM. 1987a. The effects of polychlorinated biphenyls and methyhnercury, singly and in combination on mink. 2. Reproduction and kit development. Arch Environ Contam Toxicol 16 449 54. 

Black, D.E., R. Gutjahr-Gobell, R.J. Pruell, B. Bergen, and A.E. McElroy. 1998a. Effects of a mixture of non-ortho- and mono-ortho-polychlorinated biphenyls on reproduction in Fundulus heteroclitus (Linneaus). Environ. Toxicol. Chem. 17 1396-1404. 

Polybrominated Biphenyls. PBBs have the potential to interact with the endocrine system based on effects that mainly include changes in levels of thyroid and female reproductive hormones. No studies were located that investigated the estrogenic and antiestrogenic activity of PBBs in vitro or in vivo at the level of the estrogen receptor. 

Faroon OM, Keith S, Jones D, and deRosa C (2001) Effects of polychlorinated biphenyls on development and reproduction. Toxicology and Industrial Health 17 63-93. 

Although drugs such as acetaminophen bind to AhR, the majority of AhR agonists or antagonists are environmental chemicals. Polychlorinated diben-zodioxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), dibenzofu-rans, biphenyls, and a number of other chemicals are widespread pollutants in aquatic ecosystems. These compounds cause a high reproductive and developmental toxicity, which is mediated via binding to the AhR. Thus they pose a serious threat to many populations of mammals, birds, and fish. Various adverse effects—including structural malformations, reduced fertility, tumor promotion, immunotoxicity, and skin disorders like chloracne—have been observed [139]. 

Bleavins MR, Aulerich RJ, Ringer RK. 1980. Polychlorinated biphenyls (Aroclors 1016 and 1242) Effects on survival and reproduction in mink and ferrets. Arch Environ Contam Toxicol 9 627-635. 

Gray LE Jr, Ostby J, Marshall R, et al. 1993. Reproductive and th)Toid effects of low-level polychlorinated biphenyl (Aroclor 1254) exposure. Fundam Appl Toxicol 20(3) 288-294. 

Hansen LG, Byerly CS, Metcalf RL, et al. 1975. Effect of a polychlorinated biphenyl mixture on swine reproduction and tissue residues. Am J Vet Res 36 23-26. 

Linder RE, Gaines TB, Kimbrough RD. 1974. The effect of polychlorinated biphenyls on rat reproduction. Food Cosmet Toxicol 12 63-77. 

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