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Biotransformation processes hydrolysis

This biotransformation process takes place principally in the liver, i.e. in the smooth endoplasmic reticulum, partly also in the mitochondria. The kidneys, lungs, intestine, muscles, spleen and skin are involved to a lesser degree in biotransformation. Through hydrolysis and reduction, the intestinal flora may also play a role in this metabolic process. Biotransformation is limited by the hepatic blood flow (= flow-limited elimination) and by the capacity of microsomal enzyme systems (= capacity-limited elimination). (80, 95)... [Pg.53]

The first two of these reactions are equally relevant for biotransformation process. Amides are often more stable to enzymatic hydrolysis than the corresponding esters with similar structures. For example, phenyl-acetate is hydrolyzed much faster than acetanilide. In addition, CarbE can hydrolyze therapeutically useful drug esters, such as chloramphenicol succinate, prednisolone succinate, procaine, and methylparaben. [Pg.432]

Biotransformation is not strictly related to detoxication, because in a number of cases the metabolites are more toxic than the parent pollutants, and in that case, the term of bioactivation or toxication is used. Metabolites may have comparable or greater toxicity in organism than the parent pollutant since during the biotransformation process functional groups are inserted into the pollutant by oxidation, reduction or hydrolysis reactions. [Pg.260]

PROBABLE FATE photolysis C-C bond photolysis can occur, not important in aquatic systems, photooxidation by U.V. light in aqueous medium 90-95°C, time for the formation of CO2 (% theoretical) 24% 3 hr, 50% 17.4 hr, 75% 45.8 hr, photooxidation in air 9.24 hrs-3.85 days oxidation probably not an important process hydrolysis very slow, not important, first-order hydrolytic half-life 207 days volatilization not an important process, calculated half-life in water 4590 hr 25°C and 1 m depth, based on an evaporation rate of 1.5x10 m/hr sorption important for transport to anaerobic sludges, 30-40% adsorbed on aquifer sand 5°C after 3-100 hr equilibrium time, 75-100% disappearance from soils 3-10 yrs biological processes biotransformation is the most important process other reac-tions/interactions electrochemical reduction with products of benzene and gamma-TCCH has been studied... [Pg.252]

Other relevant metabolic pathways result in detoxified substances, such as biotransformation processes in the liver — conjugation wifli glycine, glucuronic acid and sulphuric acid (e.g., via hydroxylation of toluene) or biotransformation by hydrolysis, oxidation and conjugation (e.g., glycol ethers). [Pg.1317]

Bromomethanes. Hydrolysis (hydrolytic half-life = 20 days) and volatilization are the important processes in the fate of bromomethanes in water. Once volatilized, photooxidation yielding bromine atoms and inorganic bromides and diffusion to stratosphere with subsequent photodissociation will probably determine the fate of bromomethanes. At present, the importance of sorption and biotransformation processes in the fate of these compounds in the aquatic environment is not known. [Pg.27]

Biotransformation reactions can be classified as phase 1 and phase 11. In phase 1 reactions, dmgs are converted to product by processes of functionalization, including oxidation, reduction, dealkylation, and hydrolysis. Phase 11 or synthetic reactions involve coupling the dmg or its polar metaboHte to endogenous substrates and include methylation, acetylation, and glucuronidation (Table 1). [Pg.269]

D-Pantolactone and L-pantolactone are used as chiral intermediates in chemical synthesis, whereas pantoic acid is used as a vitamin B2 complex. All can be obtained from racemic mixtures by consecutive enzymatic hydrolysis and extraction. Subsequently, the desired hydrolysed enantiomer is lactonized, extracted and crystallized (Figure 4.6). The nondesired enantiomer is reracemized and recycled into the plug-flow reactor [33,34]. Herewith, a conversion of 90-95% is reached, meaning that the resolution of racemic mixtures is an alternative to a possible chiral synthesis. The applied y-lactonase from Fusarium oxysporum in the form of resting whole cells immobilized in calcium alginate beads retains more than 90% of its initial activity even after 180 days of continuous use. The biotransformation yielding D-pantolactone in a fixed-bed reactor skips several steps here that are necessary in the chemical resolution. Hence, the illustrated process carried out by Fuji Chemical Industries Co., Ltd is an elegant way for resolution of racemic mixtures. [Pg.86]

Despite the diverse range of documented enzyme-catalyzed reactions, there are only certain types of transformations that have thus far emerged as synthetically useful. These reactions are the hydrolysis of esters, reduction/oxidation reactions, and the formation of carbon-carbon bonds. The first part of this chapter gives a brief overview by describing some examples of various biotransformations that can easily be handled and accessed by synthetic organic chemists. These processes are now attracting more and more attention from nonspecialists of enzymes. [Pg.451]

Most often, the rates for feedstock destruction in anaerobic digestion systems are based upon biogas production or reduction of total solids (TS) or volatile solids (VS) added to the system. Available data for analyses conducted on the specific polymers in the anaerobic digester feed are summarized in Table II. The information indicates a rapid rate of hydrolysis for hemicellulose and lipids. The rates and extent of cellulose degradation vary dramatically and are different with respect to the MSW feedstock based on the source and processing of the paper and cardboard products (42). Rates for protein hydrolysis are particularly difficult to accurately determine due the biotransformation of feed protein into microbial biomass, which is representative of protein in the effluent of the anaerobic digestion system. [Pg.25]

Two types of enzymatic pathways, the so-called phase I and phase II pathways, are generally implicated in drug biotransformation. Phase I pathways correspond to functionalization processes, whereas phase II correspond to biosynthetic or conjugative processes. Phase I functionalization processes include oxidation, reduction, hydrolysis, hydration, and isomerization reactions. [Pg.18]

Comparison of kh with the calculated k,ot = 0.15 d 1 shows that abiotic hydrolysis is the most important removal mechanism for BzC in the pond ( 75%>) thus, you have to worry about the transformation product benzyl alcohol (Fig. 12.1). About 7% is removed by flushing (kw = VIQ = 0.01 d"1), and the rest by other processes. Considering the properties of benzyl chloride (e.g., Kj0Vi, Ajaw, see Appendix C), the most likely additional elimination processes are gas exchange and biotransformation (see later chapters). [Pg.485]

One of the best examples for discussing biotransformations in neat solvents is the enzymatic hydrolysis of acrylonitrile, a solvent, to acrylamide, covered in Chapter 7, Section 7.1.1.1. For several applications of acrylamide, such as polymerization to polyacrylamide, very pure monomer is required, essentially free from anions and metals, which is difficult to obtain through conventional routes. In Hideaki Yamada s group (Kyoto University, Kyoto, Japan), an enzymatic process based on a nitrile hydratase was developed which is currently run on a commercial scale at around 30 000-40 000 tpy with resting cells of third-generation biocatalyst from Rhodococcus rhodochrous J1 (Chapter 7, Figure 7.1). [Pg.355]

Biotransformation refers to changes in xenobiotic compounds as a result of enzyme action. Reactions not mediated by enzymes may also be important. As examples of nonenzymatic transformations, some xenobiotic compounds bond with endogenous biochemical species without an enzyme catalyst, undergo hydrolysis in body fluid media, or undergo oxidation-reduction processes. However, the metabolic phase I and phase II reactions of xenobiotics discussed here are enzymatic. [Pg.160]

In contrast to the oxidative reactions discussed above, the only reported biotransformations of reserpine (21) and rescinnamine (23) (42-44) appear to involve hydrolytic processes. Reserpine is readily metabolized by liver homogenates from the mouse (43), rat, guinea pig, dog, and cat (44) to yield methyl reserpate (22) and 3,4,5-trimethoxybenzoic acid in yields of up to 70% (43). The use of reserpine labeled with tritium in the 2 and 6 positions of the trimethoxybenzoate residue indicated that no significant metabolism of reserpine by another route occurred before hydrolysis, reserpine and 3,4,5-trimethoxybenzoic acid being the only detectable radioactive components of the incubation mixture at the conclusion of the reaction (44). An... [Pg.336]

Biotransformation or metabolic inactivation of drugs occurs mainly in the liver and, to a lesser extent, in the plasma, kidney, and other tissues, depending on the enzyme system involved. In the liver, microsomal enzymes catalyze many of the metabolic processes involved in the biotransformation of drugs. These metabolic processes may involve nonsynthetic reactions such as oxidation, reduction, or hydrolysis, or synthetic reactions, including conjugation, whereby the drug is coupled with an endogenous substrate (53). [Pg.258]


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Biotransformation processes

Hydrolysis processes

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