Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Fuji Chemical Industries

BioReal Inc., Kihei, Hawaii, U.S., a subsidiary of Fuji Chemical Industry, Toyama, Japan... [Pg.409]

D-Pantolactone and L-pantolactone are used as chiral intermediates in chemical synthesis, whereas pantoic acid is used as a vitamin B2 complex. All can be obtained from racemic mixtures by consecutive enzymatic hydrolysis and extraction. Subsequently, the desired hydrolysed enantiomer is lactonized, extracted and crystallized (Figure 4.6). The nondesired enantiomer is reracemized and recycled into the plug-flow reactor [33,34]. Herewith, a conversion of 90-95% is reached, meaning that the resolution of racemic mixtures is an alternative to a possible chiral synthesis. The applied y-lactonase from Fusarium oxysporum in the form of resting whole cells immobilized in calcium alginate beads retains more than 90% of its initial activity even after 180 days of continuous use. The biotransformation yielding D-pantolactone in a fixed-bed reactor skips several steps here that are necessary in the chemical resolution. Hence, the illustrated process carried out by Fuji Chemical Industries Co., Ltd is an elegant way for resolution of racemic mixtures. [Pg.86]

In the nineties a process for the kinetic resolution of pantolactone by enantio-selective hydrolysis was developed by Yamada and coworkers with Fuji Chemical Industries, Japan (now Daiichi Fine Chemical) using the fungus Fusarium oxy-sporum AKU3702 [13]. Like most of the Fusarium strains and strains of the related species Gibberella, Cylindrocarpon, Penicillium, and Aspergillus, Fusarium oxysporum... [Pg.504]

Fuji Chemical Industry Co. Technical Literature Bulk Pharmaceuticals Fujicalin. (http // www.fujichemical.co.jp/). Accessed 12 October 2007. [Pg.202]

Fuji Chemical Industry Co. 1996. Calcium hydrogen phosphate, a method for preparing it and an excipient utilizing it. U.S. patent no. 5,486,365. [Pg.202]

Grades of anhydrous dibasic calcium phosphate available for direct compression include A-TAB (Rhodia), Di-Cafos AN (Chemische Fabrik Budenheim), Emcompress Anhydrous (JRS Pharma LP), and Fujicalin (Fuji Chemical Industry Co. Ltd.). The EINECS number for calcium phosphate is 231-837-1. [Pg.94]

Fuji Chemical Industry Co. Ltd. Technical literature Fujicalin, 1998. Rhodia. Technical literature Calcium phosphate excipients, 1999. [Pg.95]

Brenntag Inc Charkit Chemical Corp Fuji Chemical Industries Health Science (USA) Inc... [Pg.838]

American Colloid Co Fuji Chemical Industries Health Science (USA) Inc Kraft Chemical Co Mutchler Inc Penta Manufacturing Co RT Vanderbilt Company Inc Spectrum Quality Products Inc Whittaker Clark, and Daniels Inc... [Pg.847]

Figure 19 17. Synthesis of D-pantolactone (Fuji Chemical Industries). Figure 19 17. Synthesis of D-pantolactone (Fuji Chemical Industries).
About 6,0001 of the animal feed additive calcium-D-pantothenate are produced annually via D-pantolactone (d-112) (Scheme 35, left side).D-Pantolactone itself is an important chiral intermediate for chemical synthesis and a chiral resolution agent for optically pure amines. Optically pure d-112 is for instance produced by Fuji Chemical Industries by using the D-specific 1,4-lactone hydroxy-acylhydrolase from Fusarium oxysporum [100-102], an enzyme that catalyzes the stereospecific hydrolysis of various kinds of lactones. Treatment of mc-112 leads to an exclusive hydrolysis of d-112 the hydroxy acid d-113 can be easily separated from the remaining lactone l-1 12 and is subsequently chemically con-... [Pg.297]

See other pages where Fuji Chemical Industries is mentioned: [Pg.63]    [Pg.295]    [Pg.178]    [Pg.63]    [Pg.838]    [Pg.847]    [Pg.874]    [Pg.880]    [Pg.16]    [Pg.1692]    [Pg.1692]    [Pg.5953]    [Pg.5953]    [Pg.10]    [Pg.42]    [Pg.320]    [Pg.2892]   
See also in sourсe #XX -- [ Pg.1433 ]



SEARCH



© 2024 chempedia.info